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    CtsL4 Cathepsin L4 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34401, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CtsL4provided by FlyBase
    Official Full Name
    Cathepsin L4provided by FlyBase
    Primary source
    FLYBASE:FBgn0032228
    Locus tag
    Dmel_CG5367
    See related
    AllianceGenome:FB:FBgn0032228
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5367; CTS L; Cts10; Dmel\CG5367
    Summary
    Predicted to enable cysteine-type endopeptidase activity. Predicted to be involved in proteolysis involved in protein catabolic process. Predicted to be active in extracellular space and lysosome. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CtsL4 in Genome Data Viewer
    Location:
    31D10-31D10; 2-41 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10354743..10356597, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10354743..10356597, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene FERM domain containing Neighboring gene uncharacterized protein Neighboring gene Caseinolytic protease proteolytic subunit Neighboring gene Cullin-associated and neddylation-dissociated 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural and functional conservation profiles of novel cathepsin L-like proteins identified in the Drosophila melanogaster genome. Kumar S, et al. J Biomol Struct Dyn, 2013 Dec. PMID 23256878
    2. Comparison of dot chromosome sequences from D. melanogaster and D. virilis reveals an enrichment of DNA transposon sequences in heterochromatic domains. Slawson EE, et al. Genome Biol, 2006. PMID 16507169, Free PMC Article
    3. Evolution of a distinct genomic domain in Drosophila: comparative analysis of the dot chromosome in Drosophila melanogaster and Drosophila virilis. Leung W, et al. Genetics, 2010 Aug. PMID 20479145, Free PMC Article
    4. Functional proteomics of the active cysteine protease content in Drosophila S2 cells. Kocks C, et al. Mol Cell Proteomics, 2003 Nov. PMID 13130081
    5. piggyBac-based insertional mutagenesis and enhancer detection as a tool for functional insect genomics. Horn C, et al. Genetics, 2003 Feb. PMID 12618403, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis involved in protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cathepsin L4
    Names
    CG5367-PA
    CtsL4-PA
    NP_609387.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      10354743..10356597 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135543.2 → NP_609387.1  cathepsin L4 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609387.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VKY4
      Related
      FBpp0079644
      Conserved Domains (2) summary
      cd02248
      Location:128 → 336
      Peptidase_C1A; Peptidase C1A subfamily (MEROPS database nomenclature); composed of cysteine peptidases (CPs) similar to papain, including the mammalian CPs (cathepsins B, C, F, H, L, K, O, S, V, X and W). Papain is an endopeptidase with specific substrate preferences, ...
      pfam08246
      Location:36 → 96
      Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VKY4 Q9VKY4

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