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    PrBP Prenyl-binding protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34196, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PrBPprovided by FlyBase
    Official Full Name
    Prenyl-binding proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032059
    Locus tag
    Dmel_CG9296
    See related
    AllianceGenome:FB:FBgn0032059
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9296; Dmel\CG9296; DmPrBP; DmPrBP/delta
    Summary
    Predicted to be involved in sensory perception of light stimulus. Located in cytoplasm and nucleus. Is expressed in dorsal pharyngeal muscle cell; larval muscle system; and organism. Human ortholog(s) of this gene implicated in Joubert syndrome 22. Orthologous to human PDE6D (phosphodiesterase 6D). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See PrBP in Genome Data Viewer
    Location:
    29E3-29E3; 2-33 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (8684823..8685955, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (8684823..8685955, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene transfer RNA:Aspartic acid-GTC 1-8 Neighboring gene transfer RNA:Aspartic acid-GTC 1-9 Neighboring gene uncharacterized protein Neighboring gene TRAPP subunit 23 Neighboring gene Hepatocyte nuclear factor 4 Neighboring gene antisense RNA:CR44992

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Regulation of a Drosophila melanogaster cGMP-specific phosphodiesterase by prenylation and interaction with a prenyl-binding protein. Day JP, et al. Biochem J, 2008 Sep 15. PMID 18503409
    2. Differential microarray analysis of Drosophila mushroom body transcripts using chemical ablation. Kobayashi M, et al. Proc Natl Acad Sci U S A, 2006 Sep 26. PMID 16971484, Free PMC Article
    3. Drosophila HNF4 regulates lipid mobilization and beta-oxidation. Palanker L, et al. Cell Metab, 2009 Mar. PMID 19254568, Free PMC Article
    4. Functional screening of mammalian mechanosensitive genes using Drosophila RNAi library- Smarcd3/Bap60 is a mechanosensitive pro-inflammatory gene. Kumar S, et al. Sci Rep, 2016 Nov 7. PMID 27819340, Free PMC Article
    5. Next-generation large-scale binary protein interaction network for Drosophila melanogaster. Tang HW, et al. Nat Commun, 2023 Apr 15. PMID 37061542, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in sensory perception of light stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Prenyl-binding protein
    Names
    CG9296-PA
    PrBP-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      8684823..8685955 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135402.3 → NP_609246.1  Prenyl-binding protein [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609246.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VLJ0
      UniProtKB/TrEMBL
      A0A1B2AJR5
      Related
      FBpp0079352
      Conserved Domains (1) summary
      pfam05351
      Location:11 → 150
      GMP_PDE_delta; GMP-PDE, delta subunit
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VLJ0.1 Q9VLJ0

    Gene LinkOut

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