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    Snx1 Sorting nexin 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33560, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Snx1provided by FlyBase
    Official Full Name
    Sorting nexin 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0031534
    Locus tag
    Dmel_CG2774
    See related
    AllianceGenome:FB:FBgn0031534
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG2774; Dmel\CG2774; Dsnx1; snx1; Vps5
    Summary
    Predicted to enable phosphatidylinositol-3-phosphate binding activity. Predicted to be involved in early endosome to Golgi transport. Predicted to be part of retromer, tubulation complex. Predicted to be active in endosome membrane. Is expressed in several structures, including adult head; adult heart; ganglia; germline cell; and gut section. Orthologous to human SNX1 (sorting nexin 1) and SNX2 (sorting nexin 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Snx1 in Genome Data Viewer
    Location:
    23F3-23F3; 2-10 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (3449683..3452106)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (3449683..3452106)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Polypeptide N-Acetylgalactosaminyltransferase 2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Component of oligomeric golgi complex 3 Neighboring gene Secretory 5 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular identification of a BAR domain-containing coat complex for endosomal recycling of transmembrane proteins. Simonetti B, et al. Nat Cell Biol, 2019 Oct. PMID 31576058, Free PMC Article
    2. Evolutionary reconstruction of the retromer complex and its function in Trypanosoma brucei. Koumandou VL, et al. J Cell Sci, 2011 May 1. PMID 21502137, Free PMC Article
    3. Regulating gene expression in the Drosophila germ line. Rangan P, et al. Cold Spring Harb Symp Quant Biol, 2008. PMID 19270081
    4. Mistargeting of secretory cargo in retromer-deficient cells. Neuman SD, et al. Dis Model Mech, 2021 Jan 1. PMID 33380435, Free PMC Article
    5. Retromer Controls Planar Polarity Protein Levels and Asymmetric Localization at Intercellular Junctions. Strutt H, et al. Curr Biol, 2019 Feb 4. PMID 30661800, Free PMC Article

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables phosphatidylinositol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol-3-phosphate binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in early endosome to Golgi transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT involved_in positive regulation of Wnt protein secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in retrograde transport, endosome to Golgi ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of retromer, tubulation complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    sorting nexin 1
    Names
    CG2774-PA
    CG2774-PB
    Snx1-PA
    Snx1-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      3449683..3452106
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_134933.2 → NP_608777.1  sorting nexin 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608777.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MS29, Q9VQQ6
      Related
      FBpp0077206
      Conserved Domains (2) summary
      cd06859
      Location:75 → 203
      PX_SNX1_2_like; The phosphoinositide binding Phox Homology domain of Sorting Nexins 1 and 2
      cd07623
      Location:232 → 455
      BAR_SNX1_2; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexins 1 and 2

    2. NM_001298657.1 → NP_001285586.1  sorting nexin 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285586.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MS29, X2J8I7
      Conserved Domains (2) summary
      cd06859
      Location:75 → 203
      PX_SNX1_2_like; The phosphoinositide binding Phox Homology domain of Sorting Nexins 1 and 2
      cd07623
      Location:232 → 453
      BAR_SNX1_2; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexins 1 and 2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MS29 Q8MS29
    Q9VQQ6 Q9VQQ6
    X2J8I7 X2J8I7

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