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    IP3K2 Inositol 1,4,5-triphosphate kinase 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32285, updated on 9-Dec-2024

    Summary

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    Official Symbol
    IP3K2provided by FlyBase
    Official Full Name
    Inositol 1,4,5-triphosphate kinase 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0283680
    Locus tag
    Dmel_CG45017
    See related
    AllianceGenome:FB:FBgn0283680
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12724; CG15745; CG1630; CG34359; CG4501; CG45017; D-IP3K2; DIP3K2; Dmel\CG45017; dmIP3K2; dmIP3Kbeta; dmIP[[3]]beta; ip3k2; IP[[3]]K-2; IP[[3]]K2; NP2758; wy
    Old locus tag
    CG12724; CG1630; Dmel_CG12724; Dmel_CG15745; Dmel_CG1630; Dmel_CG34359
    Summary
    Enables calcium-dependent protein binding activity; calmodulin binding activity; and inositol-1,4,5-trisphosphate 3-kinase activity. Involved in autophagic cell death; inositol phosphate biosynthetic process; and negative regulation of cytosolic calcium ion concentration. Located in cytoplasm. Is expressed in several structures, including Kenyon cell; dopaminergic PPL1 neuron; embryonic/larval midgut primordium; epidermis; and gut section. Human ortholog(s) of this gene implicated in colorectal cancer. Orthologous to several human genes including ITPKB (inositol-trisphosphate 3-kinase B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See IP3K2 in Genome Data Viewer
    Location:
    11E9-11E11; 1-42 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (13303633..13329303)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (13197666..13223336)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Remoulade Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45018 Neighboring gene long non-coding RNA:CR32636 Neighboring gene Peroxiredoxin 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Regulation of inositol 1,4,5-trisphosphate 3-kinases by calcium and localization in cells. Lloyd-Burton SM, et al. J Biol Chem, 2007 Mar 30. PMID 17284449
    2. Increased Levels of the Parkinson's Disease-Associated Gene ITPKB Correlate with Higher Expression Levels of α-Synuclein, Independent of Mutation Status. Di Leva F, et al. Int J Mol Sci, 2023 Jan 19. PMID 36768321, Free PMC Article
    3. Convergence of multimodal sensory pathways to the mushroom body calyx in Drosophila melanogaster. Yagi R, et al. Sci Rep, 2016 Jul 11. PMID 27404960, Free PMC Article
    4. Functional and bioinformatics analyses reveal conservation of cis-regulatory elements between sciaridae and drosophilidae. Lecci MS, et al. Genesis, 2008 Jan. PMID 18196600
    5. The wavy Mutation Maps to the Inositol 1,4,5-Trisphosphate 3-Kinase 2 (IP3K2) Gene of Drosophila and Interacts with IP3R to Affect Wing Development. Dean DM, et al. G3 (Bethesda), 2015 Nov 27. PMID 26613949, Free PMC Article

    See all (64) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Drosophila miR-14 regulates context-specific autophagy through its target, inositol 1,4,5-trisphosphate kinase 2 (ip3k2).
      Title: miR-14 regulates autophagy during developmental cell death by targeting ip3-kinase 2.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium-dependent protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calmodulin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables inositol hexakisphosphate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables inositol-1,4,5-trisphosphate 3-kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in autophagic cell death IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in autophagic cell death IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in inositol phosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in inositol phosphate biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in inositol phosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of cytosolic calcium ion concentration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phosphatidylinositol phosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    inositol 1,4,5-triphosphate kinase 2
    Names
    CG45017-PA
    CG45017-PB
    CG45017-PC
    CG45017-PD
    CG45017-PG
    CG45017-PH
    IP3K2-PA
    IP3K2-PB
    IP3K2-PC
    IP3K2-PD
    IP3K2-PG
    IP3K2-PH
    wavy
    NP_001096969.1
    NP_001285200.1
    NP_001285201.1
    NP_572873.2
    NP_572875.1
    NP_727688.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      13303633..13329303
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298272.1 → NP_001285201.1  inositol 1,4,5-triphosphate kinase 2, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285201.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VYE7
      Conserved Domains (1) summary
      pfam03770
      Location:217 → 426
      IPK; Inositol polyphosphate kinase

    2. NM_132645.3 → NP_572873.2  inositol 1,4,5-triphosphate kinase 2, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572873.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KV26
      Conserved Domains (1) summary
      pfam03770
      Location:441 → 650
      IPK; Inositol polyphosphate kinase

    3. NM_001103499.2 → NP_001096969.1  inositol 1,4,5-triphosphate kinase 2, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001096969.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VYE7
      Conserved Domains (1) summary
      pfam03770
      Location:217 → 426
      IPK; Inositol polyphosphate kinase

    4. NM_001298271.1 → NP_001285200.1  inositol 1,4,5-triphosphate kinase 2, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285200.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VYE7
      Conserved Domains (1) summary
      pfam03770
      Location:217 → 426
      IPK; Inositol polyphosphate kinase

    5. NM_167358.2 → NP_727688.1  inositol 1,4,5-triphosphate kinase 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727688.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SXS8, Q9VYE6
      Related
      FBpp0310585
      Conserved Domains (1) summary
      pfam03770
      Location:419 → 628
      IPK; Inositol polyphosphate kinase

    6. NM_132647.2 → NP_572875.1  inositol 1,4,5-triphosphate kinase 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572875.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SXS8, Q9VYE6
      Related
      FBpp0310584
      Conserved Domains (1) summary
      pfam03770
      Location:419 → 628
      IPK; Inositol polyphosphate kinase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7KV26 Q7KV26
    Q95RU3 Q95RU3
    Q9VYE6 Q9VYE6
    Q9VYE7 Q9VYE7

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