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    NAAT1 Nutrient Amino Acid Transporter 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31457, updated on 9-Dec-2024

    Summary

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    Official Symbol
    NAAT1provided by FlyBase
    Official Full Name
    Nutrient Amino Acid Transporter 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0029762
    Locus tag
    Dmel_CG3252
    See related
    AllianceGenome:FB:FBgn0029762
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0149848.3; CG3252; Dmel\CG3252; dmNAT1; DmNAT1; Naat1
    Summary
    Enables amino acid transmembrane transporter activity. Involved in carboxylic acid transport; neutral amino acid transport; and sodium ion transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including anterior-posterior subdivision of organism; embryonic/larval salivary gland; epithelial tube; ganglia; and gut section. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See NAAT1 in Genome Data Viewer
    Location:
    4F9-4F9; 1-11 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (5405238..5410849, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (5299271..5304882, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Calcineurin B Neighboring gene small conductance calcium-activated potassium channel Neighboring gene spoonbill Neighboring gene Ubiquitin specific protease 16/45

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila spoonbill encodes a dual-specificity A-kinase anchor protein essential for oogenesis. Hadad M, et al. Mech Dev, 2011 Sep-Dec. PMID 21983075
    2. Organization of Circadian Behavior Relies on Glycinergic Transmission. Frenkel L, et al. Cell Rep, 2017 Apr 4. PMID 28380364
    3. Comparative sequence analysis and tissue localization of members of the SLC6 family of transporters in adult Drosophila melanogaster. Thimgan MS, et al. J Exp Biol, 2006 Sep. PMID 16916974
    4. The invertebrate B(0) system transporter, D. melanogaster NAT1, has unique d-amino acid affinity and mediates gut and brain functions. Miller MM, et al. Insect Biochem Mol Biol, 2008 Oct. PMID 18718864, Free PMC Article
    5. Genetic and functional studies implicate synaptic overgrowth and ring gland cAMP/PKA signaling defects in the Drosophila melanogaster neurofibromatosis-1 growth deficiency. Walker JA, et al. PLoS Genet, 2013 Nov. PMID 24278035, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables D-amino acid transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables L-amino acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-amino acid transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables amino acid:monoatomic cation symporter activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    enables amino acid:sodium symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables amino acid:sodium symporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables neurotransmitter transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables neutral L-amino acid transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in D-amino acid transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in L-amino acid transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in amino acid transmembrane transport ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    involved_in glycine import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neurotransmitter transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in neutral amino acid transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in sodium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sodium ion transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IC
    Inferred by Curator
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    nutrient amino acid transporter 1
    Names
    CG3252-PA
    NAAT1-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      5405238..5410849 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_131991.3 → NP_572219.1  nutrient amino acid transporter 1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572219.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q1AK15, Q8MRC8, Q9W4C5
      UniProtKB/TrEMBL
      C7LA87
      Related
      FBpp0070763
      Conserved Domains (1) summary
      cd10324
      Location:40 → 533
      SLC6sbd; Solute carrier 6 family, neurotransmitter transporters; solute-binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W4C5.2 Q9W4C5

    Gene LinkOut

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