SREBP Sterol regulatory element binding protein [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: SREBPprovided by FlyBase
Official Full Name: Sterol regulatory element binding proteinprovided by FlyBase
Primary source: FLYBASE:FBgn0261283
Locus tag: Dmel_CG8522
See related: AllianceGenome:FB:FBgn0261283
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG8522; Dmel\CG8522; dsrebp; dSrebp; dSREBP; HlH106; HLH106; l(3)76BDw; SREBF1; srebp; Srebp; SREBP1
Summary: Enables DNA-binding transcription activator activity, RNA polymerase II-specific. Involved in several processes, including SREBP signaling pathway; fatty acid homeostasis; and lipid droplet formation. Located in endoplasmic reticulum membrane and nuclear membrane. Is expressed in several structures, including embryonic/larval midgut cell; embryonic/larval midgut primordium; gut section; oenocyte; and visceral mesoderm derivative. Used to study heart conduction disease. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); diabetes mellitus (multiple); prostate cancer; sarcoma; and vascular dementia. Orthologous to several human genes including SREBF2 (sterol regulatory element binding transcription factor 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 76C5-76C6; 3-46 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (19793935..19798979)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (19787035..19792079)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

constitutive activation of the TOR-pathway target and lipogenesis factor Sterol regulatory element binding protein (SREBP) also resulted in GSC loss, whereas inhibition of SREBP rescued GSC loss triggered by depletion of dMfn.
Title: Mitochondrial fusion regulates lipid homeostasis and stem cell maintenance in the Drosophila testis.
The dendrite simplification in srebp mutant nociceptive neurons is accompanied by hypersensitivity of srebp mutant larvae to noxious stimuli.
Title: Cell-Autonomous Control of Neuronal Dendrite Expansion via the Fatty Acid Synthesis Regulator SREBP.
During the larval-pupal transition, the levels of CDK8 inversely correlate with the activity of sterol regulatory element binding protein.
Title: CDK8-Cyclin C Mediates Nutritional Regulation of Developmental Transitions through the Ecdysone Receptor in Drosophila.
TORC1-SREBP serves to integrate signals promoting growth and G1-S progression in order to maintain enodplasmic reticulum function during cell proliferation.
Title: Signaling networks converge on TORC1-SREBP activity to promote endoplasmic reticulum homeostasis.
dScap and dS2P, essential components of the SREBP activation machinery in mammalian cells, are dispensable in Drosophila owing to different compensatory mechanisms.
Title: Activation of sterol regulatory element binding proteins in the absence of Scap in Drosophila melanogaster.
sterol regulatory element-binding protein is activated by the caspase Drice in Drosophila larvae
Title: Activation of sterol regulatory element-binding protein by the caspase Drice in Drosophila larvae.
Larvae have an alternative cleavage mechanism for producing transcriptionally active dSREBP, and this permits survival of dS2P mutants.
Title: Alternative processing of sterol regulatory element binding protein during larval development in Drosophila melanogaster.
phosphatidylethanolamine, the major phospholipid in Drosophila, controls the release of sterol regulatory element-binding protein (SREBP) from Drosophila cell membranes, exerting feedback control on the synthesis of fatty acids and phospholipids
Title: Regulation of SREBP processing and membrane lipid production by phospholipids in Drosophila.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in SREBP signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in fatty acid homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipid droplet formation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of autophagy of mitochondrion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: sterol regulatory element binding protein

Names: CG8522-PA; CG8522-PB; CG8522-PC; CG8522-PD; SREBP-PA; SREBP-PB; SREBP-PC; SREBP-PD; drosophila sterol regulatory element binding protein; helix loop helix protein 106; lethal (3) 76BDw; sterol regulatory element-binding protein; sterol response element binding protein; sterol-responsive element-binding protein; transcription factor sterol regulatory element binding protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

19793935..19798979

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001275135.1 → NP_001262064.1 sterol regulatory element binding protein, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262064.1

Status: REVIEWED

UniProtKB/TrEMBL

Q24146, Q9VW37

Conserved Domains (2) summary

cd00083
Location:281 → 338

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

pfam03938
Location:289 → 364

OmpH; Outer membrane protein (OmpH-like)
NM_168816.2 → NP_730450.1 sterol regulatory element binding protein, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_730450.1

Status: REVIEWED

UniProtKB/TrEMBL

Q24146, Q9VW37

Related

FBpp0074643

Conserved Domains (2) summary

cd00083
Location:281 → 338

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

pfam03938
Location:289 → 364

OmpH; Outer membrane protein (OmpH-like)
NM_168815.2 → NP_730449.1 sterol regulatory element binding protein, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_730449.1

Status: REVIEWED

UniProtKB/TrEMBL

Q24146, Q9VW37

Related

FBpp0074642

Conserved Domains (2) summary

cd00083
Location:281 → 338

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

pfam03938
Location:289 → 364

OmpH; Outer membrane protein (OmpH-like)
NM_079442.3 → NP_524166.2 sterol regulatory element binding protein, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524166.2

Status: REVIEWED

UniProtKB/TrEMBL

Q24146, Q9VW37

Related

FBpp0074644

Conserved Domains (2) summary

cd00083
Location:281 → 338

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

pfam03938
Location:289 → 364

OmpH; Outer membrane protein (OmpH-like)