tup tailup [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: tupprovided by FlyBase
Official Full Name: tailupprovided by FlyBase
Primary source: FLYBASE:FBgn0003896
Locus tag: Dmel_CG10619
See related: AllianceGenome:FB:FBgn0003896
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG10619; Dmel\CG10619; isl; Isl; islet; Islet; l(2)37Aa; l(2)E41; Tailup; Tup; TUP
Summary: Enables DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in several processes, including embryonic development via the syncytial blastoderm; neuron projection guidance; and notum cell fate specification. Located in nucleus. Is expressed in several structures, including adult uniglomerular antennal lobe projection neurons; dorsal vessel wall cell; ganglia; lineage NB3-1 primary motor neurons; and segmentally-repeated neuroblast. Human ortholog(s) of this gene implicated in atrial fibrillation; congenital heart disease (multiple); diabetes mellitus (multiple); dilated cardiomyopathy; and myocardial infarction. Orthologous to human ISL1 (ISL LIM homeobox 1) and ISL2 (ISL LIM homeobox 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 37B1-37B1; 2-54 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (18859507..18881261, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (18859507..18881261, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tailup expression in Drosophila larval and adult cardiac valve cells.
Title: Tailup expression in Drosophila larval and adult cardiac valve cells.
tup interacts with Chip to regulate the generation of different cardiac cell types. Tup directly regulates eve expression.
Title: Chip/Ldb1 interacts with Tailup/islet1 to regulate cardiac gene expression in Drosophila.
Reinitiation of a transcriptional program previously employed for embryonic alary muscle development, in which the factors Org-1 and Tailup are key components, leads to the development of adult Drosophila ventral longitudinal heart muscles.
Title: Org-1-dependent lineage reprogramming generates the ventral longitudinal musculature of the Drosophila heart.
An Org-1-Tup transcriptional cascade reveals different types of alary muscles connecting internal organs in Drosophila.
Title: An Org-1-Tup transcriptional cascade reveals different types of alary muscles connecting internal organs in Drosophila.
Tailup is expressed in the main Drosophila cardiac outflow components, i.e., heart anchoring cells (HANC) and cardiac outflow muscles (COM) and that loss of its function and/or tissue-specific knockdowns dramatically affect cardiac outflow morphogenesis.
Title: Tailup plays multiple roles during cardiac outflow assembly in Drosophila.
These observations provide evidence for combinatorial activity of Isl and Lim3 in regulating ion channel gene expression
Title: The transcription factors islet and Lim3 combinatorially regulate ion channel gene expression.
Tup/Islet1 integrates time and position to specify muscle identity in Drosophila.
Title: Tup/Islet1 integrates time and position to specify muscle identity in Drosophila.
This study demonistratedt that therole of Islet on the excitability patterns characteristic of motoneuron subtypes.
Title: The LIM-homeodomain protein islet dictates motor neuron electrical properties by regulating K(+) channel expression.
Tailup is required to activate achaete and scute at the dorsocentral region, probably by acting as an hexameric complex with the cofactor Chip and the transcriptional activator Sspd on the dorsocentral enhancer of the achaete-scute complex.
Title: The pronotum LIM-HD gene tailup is both a positive and a negative regulator of the proneural genes achaete and scute of Drosophila.
The early expression of Tup in the cardiac mesoderm suggests that Tup functions in cardiac specification.
Title: The Drosophila homolog of vertebrate Islet1 is a key component in early cardiogenesis.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in amnioserosa maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axonogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in chaeta development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chaeta morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dendrite guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal closure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic heart tube development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ-band shortening	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in head involution	NAS Non-traceable Author Statement more info	PubMed
involved_in heart development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lymph gland development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in motor neuron axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in muscle cell fate determination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron fate specification	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuron fate specification	IEA Inferred from Electronic Annotation more info
involved_in notum cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: tailup

Names: CG10619-PA; CG10619-PB; CG10619-PC; dIslet; islet; islet 1; lethal(2)37Aa; tail-up; tailup/islet; tup-PA; tup-PB; tup-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

18859507..18881261 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_057427.3 → NP_476775.1 tailup, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_476775.1

Status: REVIEWED

UniProtKB/TrEMBL

P92031, Q9VJ37

Related

FBpp0080661

Conserved Domains (3) summary

cd09366
Location:54 → 108

LIM1_Isl; The first LIM domain of Isl, a member of LHX protein family

cd09374
Location:116 → 171

LIM2_Isl; The second LIM domain of Isl, a member of LHX protein family

smart00389
Location:241 → 297

HOX; Homeodomain
NM_057426.4 → NP_476774.1 tailup, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_476774.1

Status: REVIEWED

UniProtKB/TrEMBL

P92031, Q9Y0Z9

Related

FBpp0080662

Conserved Domains (3) summary

cd09366
Location:54 → 108

LIM1_Isl; The first LIM domain of Isl, a member of LHX protein family

cd09374
Location:116 → 171

LIM2_Isl; The second LIM domain of Isl, a member of LHX protein family

smart00389
Location:241 → 297

HOX; Homeodomain
NM_001299139.1 → NP_001286068.1 tailup, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001286068.1

Status: REVIEWED

UniProtKB/TrEMBL

P92031, Q9VJ37

Conserved Domains (3) summary

cd09366
Location:54 → 108

LIM1_Isl; The first LIM domain of Isl, a member of LHX protein family

cd09374
Location:116 → 171

LIM2_Isl; The second LIM domain of Isl, a member of LHX protein family

smart00389
Location:241 → 297

HOX; Homeodomain