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    Cnb Centrobin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38258, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Cnbprovided by FlyBase
    Official Full Name
    Centrobinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035295
    Locus tag
    Dmel_CG5690
    See related
    AllianceGenome:FB:FBgn0035295
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-62BCa; cDNA C; CG5690; cnb; CNB; Dmel\CG5690
    Summary
    Involved in interphase microtubule organizing center assembly and protein localization to centrosome. Located in centriole. Is expressed in several structures, including dorsal pharyngeal muscle primordium; embryonic dorsal epidermis; embryonic/larval midgut primordium; larval somatic muscle cell; and mesoderm. Orthologous to human CNTROB (centrobin, centriole duplication and spindle assembly protein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Cnb in Genome Data Viewer
    Location:
    62B11-62B11; 3-1.0 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (1947565..1950262)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (1947565..1950262)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44536 Neighboring gene Microfibril-associated protein 1 Neighboring gene mutator 2 Neighboring gene mauve Neighboring gene antisense RNA:CR45827 Neighboring gene antisense RNA:CR45828 Neighboring gene Succinyl-CoA:3-ketoacid CoA transferase Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The "transition zone" of the cilium-like regions in the Drosophila spermatocytes and the role of the C-tubule in axoneme assembly. Gottardo M, et al. Exp Cell Res, 2018 Oct 1. PMID 30130520
    2. Loss of Centrobin Enables Daughter Centrioles to Form Sensory Cilia in Drosophila. Gottardo M, et al. Curr Biol, 2015 Aug 31. PMID 26299513
    3. Drosophila neuroblasts retain the daughter centrosome. Januschke J, et al. Nat Commun, 2011. PMID 21407209, Free PMC Article
    4. Sas-4 Colocalizes with the Ciliary Rootlets of the Drosophila Sensory Organs. Persico V, et al. J Dev Biol, 2021 Jan 5. PMID 33466292, Free PMC Article
    5. Centrobin is essential for C-tubule assembly and flagellum development in Drosophila melanogaster spermatogenesis. Reina J, et al. J Cell Biol, 2018 Jul 2. PMID 29712734, Free PMC Article

    See all (54) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in centriole replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in centriole replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in centriole replication ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in centrosome separation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in interphase microtubule organizing center assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic cytokinetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to centrosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cilium assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in centriole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centriole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    centrobin
    Names
    CG5690-PA
    CG5690-PB
    Cnb-PA
    Cnb-PB
    centronobin

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      1947565..1950262
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_139423.3 → NP_647680.1  centrobin, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647680.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q960D2, Q9I7U5
      Related
      FBpp0072721
      Conserved Domains (3) summary
      pfam00261
      Location:349 → 563
      Tropomyosin; Tropomyosin
      pfam07926
      Location:291 → 408
      TPR_MLP1_2; TPR/MLP1/MLP2-like protein
      pfam08702
      Location:349 → 458
      Fib_alpha; Fibrinogen alpha/beta chain family

    2. NM_001274371.1 → NP_001261300.1  centrobin, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261300.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q960D2, Q9I7U5
      Conserved Domains (3) summary
      pfam00261
      Location:349 → 563
      Tropomyosin; Tropomyosin
      pfam07926
      Location:291 → 408
      TPR_MLP1_2; TPR/MLP1/MLP2-like protein
      pfam08702
      Location:349 → 458
      Fib_alpha; Fibrinogen alpha/beta chain family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q960D2 Q960D2
    Q9I7U5 Q9I7U5

    Gene LinkOut

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