U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Pnoc prepronociceptin [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25516, updated on 27-Nov-2024

    Summary

    Official Symbol
    Pnocprovided by RGD
    Official Full Name
    prepronociceptinprovided by RGD
    Primary source
    RGD:3362
    See related
    EnsemblRapid:ENSRNOG00000014231 AllianceGenome:RGD:3362
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    N23K; Npnc1
    Summary
    Predicted to enable opioid receptor binding activity and receptor ligand activity. Involved in chemical synaptic transmission; female pregnancy; and neuropeptide signaling pathway. Predicted to be located in extracellular region. Predicted to be active in several cellular components, including axon terminus; neuronal cell body; and synaptic membrane. Biomarker of fetal alcohol spectrum disorder. Human ortholog(s) of this gene implicated in neonatal abstinence syndrome. Orthologous to human PNOC (prepronociceptin). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Uterus (RPKM 75.9), Brain (RPKM 26.2) and 2 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Pnoc in Genome Data Viewer
    Location:
    15p12
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (43800240..43827841, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (39624635..39652463, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (48805841..48833071, complement)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120097019 Neighboring gene zinc finger protein 395 Neighboring gene elongator acetyltransferase complex subunit 3 Neighboring gene annexin A2, pseudogene1 Neighboring gene ribosomal protein S17, pseudogene 14

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables opioid peptide activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables opioid receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables receptor ligand activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in chemical synaptic transmission IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in female pregnancy IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in neuron-neuron synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuropeptide signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in neuropeptide signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in sensory perception IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in sensory perception of pain ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in axon terminus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in neuronal cell body IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in synaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    prepronociceptin
    Names
    Prepronociceptin (neuropeptide nociceptin) (N23K)
    neuropeptide nociceptin 1
    nociceptin
    orphanin FQ

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013007.1NP_037139.1  prepronociceptin precursor

      See identical proteins and their annotated locations for NP_037139.1

      Status: PROVISIONAL

      Source sequence(s)
      X97375
      UniProtKB/Swiss-Prot
      Q62923, Q64162
      UniProtKB/TrEMBL
      A6K6J8
      Related
      ENSRNOP00000019117.6, ENSRNOT00000019117.9
      Conserved Domains (1) summary
      pfam01160
      Location:2166
      Opiods_neuropep; Vertebrate endogenous opioids neuropeptide

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      43800240..43827841 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039093010.2XP_038948938.1  prepronociceptin isoform X1

      UniProtKB/TrEMBL
      A6K6J7
      Conserved Domains (1) summary
      pfam01160
      Location:2166
      Opiods_neuropep; Vertebrate endogenous opioids neuropeptide
    2. XM_006252196.5XP_006252258.1  prepronociceptin isoform X1

      See identical proteins and their annotated locations for XP_006252258.1

      UniProtKB/TrEMBL
      A6K6J7
      Conserved Domains (1) summary
      pfam01160
      Location:2166
      Opiods_neuropep; Vertebrate endogenous opioids neuropeptide
    3. XM_063273998.1XP_063130068.1  prepronociceptin isoform X2

      UniProtKB/Swiss-Prot
      Q62923, Q64162
      UniProtKB/TrEMBL
      A6K6J8