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    Sftpc surfactant protein C [ Rattus norvegicus (Norway rat) ]

    Gene ID: 50683, updated on 27-Nov-2024

    Summary

    Official Symbol
    Sftpcprovided by RGD
    Official Full Name
    surfactant protein Cprovided by RGD
    Primary source
    RGD:3666
    See related
    EnsemblRapid:ENSRNOG00000011177 AllianceGenome:RGD:3666
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    SP-C
    Summary
    Enables identical protein binding activity. Involved in several processes, including cellular response to mechanical stimulus; cellular response to nitric oxide; and response to vitamin A. Located in alveolar lamellar body; extracellular space; and multivesicular body. Biomarker of bacterial pneumonia and newborn respiratory distress syndrome. Human ortholog(s) of this gene implicated in asthma; lung disease (multiple); and respiratory syncytial virus infectious disease. Orthologous to human SFTPC (surfactant protein C). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward (RPKM 56853.0) See more
    Orthologs
    NEW
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    Genomic context

    See Sftpc in Genome Data Viewer
    Location:
    15p11
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (52006274..52009324, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (45596565..45599615, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (52211538..52214480, complement)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120097030 Neighboring gene phytanoyl-CoA 2-hydroxylase interacting protein Neighboring gene bone morphogenetic protein 1 Neighboring gene uncharacterized LOC134482143 Neighboring gene leucine-rich repeat LGI family, member 3 Neighboring gene uncharacterized LOC134482145

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in cellular response to mechanical stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to nitric oxide IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in circadian rhythm IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in respiratory gaseous exchange by respiratory system IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to cAMP IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to glucocorticoid IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to glucose IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to growth factor IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to hormone IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to hyperoxia IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to interleukin-6 IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to lipopolysaccharide IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to retinoic acid IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to vitamin A IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in alveolar lamellar body IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in alveolar lamellar body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in multivesicular body IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    surfactant protein C; pulmonary surfactant-associated protein C
    Names
    Surfactant, pulmonary-associated protein C
    pulmonary surfactant-associated proteolipid SPL(Val)
    surfactant associated protein C

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017342.2NP_059038.1  surfactant protein C

      See identical proteins and their annotated locations for NP_059038.1

      Status: PROVISIONAL

      Source sequence(s)
      X14221
      UniProtKB/Swiss-Prot
      P11685, Q52MA6
      UniProtKB/TrEMBL
      A0A8I6A637, A6HTK9
      Related
      ENSRNOP00000015032.4, ENSRNOT00000015035.6
      Conserved Domains (3) summary
      smart00019
      Location:1194
      SF_P; Pulmonary surfactant proteins
      smart01039
      Location:95194
      BRICHOS; The BRICHOS domain is found in a variety of proteins implicated in dementia, respiratory distress and cancer
      pfam08999
      Location:194
      SP_C-Propep; Surfactant protein C, N terminal propeptide

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      52006274..52009324 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039093609.2XP_038949537.1  pulmonary surfactant-associated protein C isoform X1

      UniProtKB/TrEMBL
      A0A0H2UHI8
      Conserved Domains (1) summary
      smart00019
      Location:22178
      SF_P; Pulmonary surfactant proteins