U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Cd24 CD24 molecule [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25145, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cd24provided by RGD
    Official Full Name
    CD24 moleculeprovided by RGD
    Primary source
    RGD:2298
    See related
    AllianceGenome:RGD:2298
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Cd24a
    Summary
    Predicted to enable several functions, including heat shock protein binding activity; protein kinase binding activity; and protein tyrosine kinase activator activity. Involved in immune response. Located in external side of plasma membrane. Human ortholog(s) of this gene implicated in multiple sclerosis. Orthologous to human CD24 (CD24 molecule). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 1098.2), Uterus (RPKM 704.0) and 5 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Cd24 in Genome Data Viewer
    Location:
    20q13
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (48655549..48661786)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (47074353..47079662)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (48335540..48340847)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene mitochondrial transcription rescue factor 1 Neighboring gene fractured callus expressed transcript 1, pseudogene 1 Neighboring gene uncharacterized LOC120098891 Neighboring gene uncharacterized LOC134483829

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Clone Names

    • MGC93641

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables Hsp70 protein binding  
    enables Hsp90 protein binding  
    enables carbohydrate binding  
    enables protein kinase binding  
    enables protein kinase binding PubMed 
    enables protein tyrosine kinase activator activity  
    enables protein tyrosine kinase activator activity  
    enables protein tyrosine kinase activator activity PubMed 
    Items 1 - 25 of 93
    Process Evidence Code Pubs
    acts_upstream_of B cell apoptotic process  
    acts_upstream_of B cell proliferation  
    involved_in B cell receptor transport into membrane raft  
    involved_in B cell receptor transport into membrane raft  
    acts_upstream_of CD4-positive, alpha-beta T cell proliferation  
    involved_in T cell costimulation  
    involved_in T cell costimulation PubMed 
    acts_upstream_of T cell homeostatic proliferation  
    acts_upstream_of_or_within apoptotic mitochondrial changes  
    acts_upstream_of_or_within apoptotic nuclear changes  
    acts_upstream_of_or_within apoptotic signaling pathway  
    acts_upstream_of calcium-mediated signaling  
    involved_in cell activation  
    involved_in cell activation  
    involved_in cell activation PubMed 
    involved_in cell adhesion  
    involved_in cell migration  
    involved_in cell migration PubMed 
    acts_upstream_of_or_within cell surface receptor signaling pathway  
    involved_in chemokine receptor transport out of membrane raft  
    involved_in chemokine receptor transport out of membrane raft  
    involved_in cholesterol homeostasis  
    involved_in cholesterol homeostasis PubMed 
    involved_in glomerular parietal epithelial cell differentiation  
    involved_in glomerular parietal epithelial cell differentiation  
    acts_upstream_of_or_within heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules  
    acts_upstream_of_or_within homotypic cell-cell adhesion  
    involved_in immune response PubMed 
    acts_upstream_of integrin activation  
    acts_upstream_of_or_within leukocyte cell-cell adhesion  
    acts_upstream_of_or_within leukocyte migration involved in inflammatory response  
    acts_upstream_of_or_within negative regulation of B cell proliferation  
    acts_upstream_of_or_within negative regulation of T cell homeostatic proliferation  
    acts_upstream_of_or_within negative regulation of erythrocyte aggregation  
    acts_upstream_of_or_within negative regulation of erythrocyte clearance  
    involved_in negative regulation of inflammatory response to wounding  
    involved_in negative regulation of interleukin-6 production  
    involved_in negative regulation of monocyte chemotactic protein-1 production  
    acts_upstream_of_or_within negative regulation of neuroblast proliferation  
    acts_upstream_of_or_within negative regulation of neurogenesis  
    acts_upstream_of_or_within negative regulation of neuron differentiation  
    involved_in negative regulation of transforming growth factor beta3 production  
    involved_in negative regulation of transforming growth factor beta3 production PubMed 
    involved_in negative regulation of tumor necrosis factor production  
    acts_upstream_of neuroblast proliferation  
    acts_upstream_of_or_within neuromuscular synaptic transmission  
    acts_upstream_of neuron projection development  
    acts_upstream_of_or_within neuron projection development  
    acts_upstream_of peptidyl-tyrosine phosphorylation  
    involved_in podocyte differentiation  
    involved_in podocyte differentiation  
    acts_upstream_of_or_within positive regulation of B cell apoptotic process  
    acts_upstream_of_or_within positive regulation of CD4-positive, alpha-beta T cell proliferation  
    involved_in positive regulation of MAP kinase activity  
    involved_in positive regulation of MAP kinase activity PubMed 
    acts_upstream_of_or_within positive regulation of T cell homeostatic proliferation  
    acts_upstream_of_or_within positive regulation of T cell mediated immune response to tumor cell  
    involved_in positive regulation of activated T cell proliferation  
    involved_in positive regulation of activated T cell proliferation PubMed 
    acts_upstream_of_or_within positive regulation of alpha-beta T cell proliferation  
    acts_upstream_of_or_within positive regulation of calcium-mediated signaling  
    acts_upstream_of_or_within positive regulation of cell adhesion mediated by integrin  
    acts_upstream_of_or_within positive regulation of cell-cell adhesion  
    acts_upstream_of_or_within positive regulation of cell-cell adhesion mediated by integrin  
    involved_in positive regulation of cytosolic calcium ion concentration  
    involved_in positive regulation of cytosolic calcium ion concentration PubMed 
    acts_upstream_of_or_within positive regulation of inflammatory response to antigenic stimulus  
    involved_in positive regulation of inflammatory response to wounding  
    acts_upstream_of_or_within positive regulation of integrin activation  
    involved_in positive regulation of nephron tubule epithelial cell differentiation  
    involved_in positive regulation of nephron tubule epithelial cell differentiation  
    acts_upstream_of_or_within positive regulation of neuron projection development  
    acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation  
    acts_upstream_of_or_within pre-B cell differentiation  
    acts_upstream_of_or_within regulation of B cell differentiation  
    involved_in regulation of MAPK cascade  
    involved_in regulation of MAPK cascade PubMed 
    involved_in regulation of cell-cell adhesion  
    acts_upstream_of_or_within regulation of cell-cell adhesion  
    acts_upstream_of_or_within regulation of cell-cell adhesion mediated by integrin  
    involved_in regulation of cytokine-mediated signaling pathway  
    involved_in regulation of cytokine-mediated signaling pathway PubMed 
    involved_in regulation of phosphorylation  
    involved_in regulation of phosphorylation PubMed 
    involved_in respiratory burst  
    involved_in respiratory burst PubMed 
    involved_in response to estrogen  
    involved_in response to estrogen PubMed 
    involved_in response to hypoxia  
    involved_in response to hypoxia PubMed 
    involved_in response to molecule of bacterial origin  
    involved_in response to molecule of bacterial origin PubMed 
    acts_upstream_of_or_within synaptic vesicle endocytosis  
    Items 1 - 25 of 93
    Component Evidence Code Pubs
    located_in cell surface  
    located_in cell surface  
    located_in ciliary membrane  
    is_active_in external side of plasma membrane  
    located_in external side of plasma membrane PubMed 
    located_in external side of plasma membrane  
    located_in intracellular membrane-bounded organelle  
    located_in membrane  
    located_in membrane  
    located_in membrane PubMed 
    is_active_in membrane raft  
    located_in membrane raft  
    located_in membrane raft PubMed 
    located_in microvillus membrane  
    located_in motile cilium  
    located_in plasma membrane  
    located_in presynapse  

    General protein information

    Preferred Names
    signal transducer CD24
    Names
    CD24 antigen
    HSA
    heat-stable antigen
    nectadrin heat stable antigen

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012752.3NP_036884.1  signal transducer CD24 precursor

      See identical proteins and their annotated locations for NP_036884.1

      Status: VALIDATED

      Source sequence(s)
      BC081851, CA509517, DY315580
      UniProtKB/Swiss-Prot
      Q07490, Q0P5T1
      UniProtKB/TrEMBL
      A6K6W7
      Conserved Domains (1) summary
      pfam14984
      Location:2663
      CD24; CD24 protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      48655549..48661786
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063278972.1XP_063135042.1  signal transducer CD24 isoform X1

      UniProtKB/Swiss-Prot
      Q07490, Q0P5T1
      UniProtKB/TrEMBL
      A6K6W7
    External link. Please review our privacy policy.