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    Cryaa crystallin, alpha A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24273, updated on 27-Nov-2024

    Summary

    Official Symbol
    Cryaaprovided by RGD
    Official Full Name
    crystallin, alpha Aprovided by RGD
    Primary source
    RGD:2413
    See related
    EnsemblRapid:ENSRNOG00000047175 AllianceGenome:RGD:2413
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Crya1; Acry-1
    Summary
    This gene encodes subunit a, one of two subunits of alpha-crystallin, which is a high molecular weight, soluble aggregate and is a member of the small heat shock protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. It acts as a molecular chaperone and is the major protein in the eye lens, maintaining the transparency and refractive index of the lens. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
    Expression
    Biased expression in Spleen (RPKM 26.6) and Thymus (RPKM 5.1) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Cryaa in Genome Data Viewer
    Location:
    20p12
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (9784872..9788656)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (9783605..9787351)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (10438444..10442189)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene cystathionine beta synthase Neighboring gene U2 small nuclear RNA auxiliary factor 1 Neighboring gene uncharacterized LOC103694395 Neighboring gene uncharacterized LOC134483882

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Related articles in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables structural constituent of eye lens TAS
    Traceable Author Statement
    more info
    PubMed 
    enables structural molecule activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables unfolded protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within actin filament organization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within apoptotic process involved in morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within camera-type eye development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within embryonic camera-type eye morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lens development in camera-type eye IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in lens development in camera-type eye IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within lens development in camera-type eye ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within lens fiber cell morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within lens morphogenesis in camera-type eye ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within microtubule-based process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within mitochondrion organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of intracellular transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein folding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein refolding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein stabilization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to UV-A ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to glucocorticoid IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to heat IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in response to hydrogen peroxide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within response to hydrogen peroxide ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to lead ion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to xenobiotic stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within tubulin complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in visual perception ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    alpha-crystallin A chain
    Names
    Crystallin, alpha polypeptide A

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289737.2NP_001276666.1  alpha-crystallin A chain isoform 2

      See identical proteins and their annotated locations for NP_001276666.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) includes an alternate in-frame exon in the central coding region, compared to variant 1. The encoded isoform (2, also known as alpha Ains-crystallin) is longer, compared to isoform 1.
      Source sequence(s)
      JAXUCZ010000020
      UniProtKB/Swiss-Prot
      P24623
      UniProtKB/TrEMBL
      A6JK11
      Conserved Domains (2) summary
      pfam00525
      Location:151
      Crystallin; Alpha crystallin A chain, N terminal
      cl00175
      Location:86168
      alpha-crystallin-Hsps_p23-like; alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins.
    2. NM_012534.5NP_036666.2  alpha-crystallin A chain isoform 1

      See identical proteins and their annotated locations for NP_036666.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the shorter isoform (1).
      Source sequence(s)
      JAXUCZ010000020
      UniProtKB/TrEMBL
      A0JN13
      Related
      ENSRNOP00000108761.1, ENSRNOT00000150532.1
      Conserved Domains (2) summary
      cd06497
      Location:60145
      ACD_alphaA-crystallin_HspB4; Alpha-crystallin domain found in the small heat shock protein (sHsp) alphaA-crystallin (HspB4, 20kDa). sHsps are molecular chaperones that suppress protein aggregation and protect against cell stress, and are generally active as large oligomers ...
      pfam00525
      Location:151
      Crystallin; Alpha crystallin A chain, N terminal

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      9784872..9788656
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063278950.1XP_063135020.1  alpha-crystallin A chain isoform X1

      Related
      ENSRNOP00000112676.1, ENSRNOT00000071248.4