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    Gpam glycerol-3-phosphate acyltransferase, mitochondrial [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29653, updated on 3-Dec-2024

    Summary

    Official Symbol
    Gpamprovided by RGD
    Official Full Name
    glycerol-3-phosphate acyltransferase, mitochondrialprovided by RGD
    Primary source
    RGD:61847
    See related
    EnsemblRapid:ENSRNOG00000015124 AllianceGenome:RGD:61847
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables glycerol-3-phosphate O-acyltransferase activity. Involved in several processes, including cellular response to insulin stimulus; glycerolipid biosynthetic process; and positive regulation of triglyceride biosynthetic process. Located in mitochondrial outer membrane. Biomarker of metabolic dysfunction-associated steatotic liver disease; nephrotic syndrome; and obesity. Orthologous to human GPAM (glycerol-3-phosphate acyltransferase, mitochondrial). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Liver (RPKM 854.8), Heart (RPKM 350.2) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Gpam in Genome Data Viewer
    Location:
    1q55
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (264111599..264176112, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (254106323..254170755, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (275843823..275906880, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120100060 Neighboring gene uncharacterized LOC102553657 Neighboring gene extensin-like Neighboring gene tectorin beta Neighboring gene guanylate cyclase 2G Neighboring gene acyl-CoA synthetase long-chain family member 5 Neighboring gene zinc finger DHHC-type palmitoyltransferase 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in CDP-diacylglycerol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in activated T cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of activated T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in activation-induced cell death of T cells IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of activation-induced cell death of T cells ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in acyl-CoA metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within acyl-CoA metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to insulin stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in defense response to virus IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within defense response to virus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in diacylglycerol biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in fatty acid homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within fatty acid homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within fatty acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in glycerophospholipid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within glycerophospholipid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of activation-induced cell death of T cells IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within negative regulation of activation-induced cell death of T cells ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phosphatidic acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in phosphatidylglycerol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in phosphatidylglycerol biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phosphatidylglycerol biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in phospholipid homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within phospholipid homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of activated T cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of activated T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of multicellular organism growth IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of multicellular organism growth ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of triglyceride biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of cytokine production IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within regulation of cytokine production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to cadmium ion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to fructose IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to glucose IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within response to glucose ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to nutrient IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to nutrient levels IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in triglyceride biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in triglyceride biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in triglyceride biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within triglyceride metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in mitochondrial membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrial outer membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    glycerol-3-phosphate acyltransferase 1, mitochondrial
    Names
    GPAT
    GPAT-1
    NP_058970.1
    XP_006231687.1
    XP_006231688.1
    XP_063143835.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017274.1NP_058970.1  glycerol-3-phosphate acyltransferase 1, mitochondrial

      See identical proteins and their annotated locations for NP_058970.1

      Status: PROVISIONAL

      Source sequence(s)
      AF021348
      UniProtKB/Swiss-Prot
      O35349, P97564, P97565, P97566
      UniProtKB/TrEMBL
      A0A0G2K2U7
      Related
      ENSRNOP00000069320.1, ENSRNOT00000083215.3
      Conserved Domains (2) summary
      cd07993
      Location:201411
      LPLAT_DHAPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like
      COG2937
      Location:131663
      PlsB; Glycerol-3-phosphate O-acyltransferase [Lipid transport and metabolism]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      264111599..264176112 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063287765.1XP_063143835.1  glycerol-3-phosphate acyltransferase 1, mitochondrial isoform X2

      UniProtKB/TrEMBL
      A0A0G2K2U7
      Related
      ENSRNOP00000103828.1, ENSRNOT00000142012.1
    2. XM_006231626.5XP_006231688.1  glycerol-3-phosphate acyltransferase 1, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_006231688.1

      UniProtKB/TrEMBL
      A0A0G2JV22, A0A0G2K2U7, A6JHY2
      Conserved Domains (2) summary
      cd07993
      Location:201411
      LPLAT_DHAPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like
      COG2937
      Location:131663
      PlsB; Glycerol-3-phosphate O-acyltransferase [Lipid transport and metabolism]
    3. XM_006231625.5XP_006231687.1  glycerol-3-phosphate acyltransferase 1, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_006231687.1

      UniProtKB/TrEMBL
      A0A0G2JV22, A0A0G2K2U7, A6JHY2
      Conserved Domains (2) summary
      cd07993
      Location:201411
      LPLAT_DHAPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like
      COG2937
      Location:131663
      PlsB; Glycerol-3-phosphate O-acyltransferase [Lipid transport and metabolism]