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    Acvr1b activin A receptor type 1B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29381, updated on 27-Nov-2024

    Summary

    Official Symbol
    Acvr1bprovided by RGD
    Official Full Name
    activin A receptor type 1Bprovided by RGD
    Primary source
    RGD:735207
    See related
    EnsemblRapid:ENSRNOG00000006934 AllianceGenome:RGD:735207
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Skr2
    Summary
    Predicted to enable several functions, including ATP binding activity; I-SMAD binding activity; and activin binding activity. Predicted to contribute to activin receptor activity and growth factor binding activity. Involved in several processes, including activin receptor signaling pathway; cardiac fibroblast cell development; and positive regulation of biosynthetic process. Predicted to be located in cell surface and cytosol. Predicted to be part of activin receptor complex. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma; lung small cell carcinoma; malignant mesothelioma; pancreatic cancer; and stomach cancer. Orthologous to human ACVR1B (activin A receptor type 1B). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 81.1), Brain (RPKM 55.3) and 9 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Acvr1b in Genome Data Viewer
    Location:
    7q36
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (134164987..134208389)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (132286266..132329679)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (142817174..142858365)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain 33 Neighboring gene activin A receptor like type 1 Neighboring gene uncharacterized LOC103692984 Neighboring gene trafficking regulator and scaffold protein tamalin Neighboring gene uncharacterized LOC134479787 Neighboring gene uncharacterized LOC134479786

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables BMP receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables I-SMAD binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables I-SMAD binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables SMAD binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables activin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables activin binding IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to activin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables activin binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to activin receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables activin receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables activin receptor activity, type I IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables activin receptor activity, type I IEA
    Inferred from Electronic Annotation
    more info
     
    enables activin receptor activity, type I ISO
    Inferred from Sequence Orthology
    more info
     
    enables activin receptor activity, type I TAS
    Traceable Author Statement
    more info
    PubMed 
    enables activin receptor activity, type II IEA
    Inferred from Electronic Annotation
    more info
     
    enables growth factor binding IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to growth factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables inhibin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables inhibin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transforming growth factor beta receptor activity, type I IEA
    Inferred from Electronic Annotation
    more info
     
    enables transforming growth factor beta receptor activity, type II IEA
    Inferred from Electronic Annotation
    more info
     
    enables transforming growth factor beta receptor activity, type III IEA
    Inferred from Electronic Annotation
    more info
     
    enables transmembrane receptor protein serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in BMP signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in G1/S transition of mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in activin receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in activin receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within activin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in activin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cardiac fibroblast cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to growth factor stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in development of primary female sexual characteristics IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in extrinsic apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in extrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in hair follicle development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within hair follicle development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in in utero embryonic development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within in utero embryonic development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell growth IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of ossification ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in nodal signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in nodal signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptidyl-threonine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of activin receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of activin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of collagen biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of erythrocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of erythrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of trophoblast cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of trophoblast cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein phosphorylation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to activity IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of activin receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of activin receptor complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of activin receptor complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of receptor complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    activin receptor type-1B
    Names
    ACTR-IB
    ALK-4
    Serine/threonine-protein kinase receptor R2
    activin A receptor, type IB
    activin receptor type IB
    activin receptor-like kinase 4
    NP_954700.1
    XP_006242377.1
    XP_038934506.1
    XP_038934507.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199230.2NP_954700.1  activin receptor type-1B precursor

      See identical proteins and their annotated locations for NP_954700.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/Swiss-Prot
      P80202
      UniProtKB/TrEMBL
      A0A8I6AKG7
      Related
      ENSRNOP00000009345.6, ENSRNOT00000009345.9
      Conserved Domains (3) summary
      smart00467
      Location:177207
      GS; GS motif
      cd14143
      Location:211498
      STKc_TGFbR1_ACVR1b_ACVR1c; Catalytic domain of the Serine/Threonine Kinases, Transforming Growth Factor beta Type I Receptor and Activin Type IB/IC Receptors
      pfam01064
      Location:38104
      Activin_recp; Activin types I and II receptor domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      134164987..134208389
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039078579.2XP_038934507.1  activin receptor type-1B isoform X1

      UniProtKB/TrEMBL
      A6KCN3
      Conserved Domains (2) summary
      smart00467
      Location:125155
      GS; GS motif
      cd14143
      Location:159446
      STKc_TGFbR1_ACVR1b_ACVR1c; Catalytic domain of the Serine/Threonine Kinases, Transforming Growth Factor beta Type I Receptor and Activin Type IB/IC Receptors
    2. XM_006242315.5XP_006242377.1  activin receptor type-1B isoform X1

      See identical proteins and their annotated locations for XP_006242377.1

      UniProtKB/TrEMBL
      A6KCN3
      Conserved Domains (2) summary
      smart00467
      Location:125155
      GS; GS motif
      cd14143
      Location:159446
      STKc_TGFbR1_ACVR1b_ACVR1c; Catalytic domain of the Serine/Threonine Kinases, Transforming Growth Factor beta Type I Receptor and Activin Type IB/IC Receptors
    3. XM_039078578.2XP_038934506.1  activin receptor type-1B isoform X1

      UniProtKB/TrEMBL
      A6KCN3
      Conserved Domains (2) summary
      smart00467
      Location:125155
      GS; GS motif
      cd14143
      Location:159446
      STKc_TGFbR1_ACVR1b_ACVR1c; Catalytic domain of the Serine/Threonine Kinases, Transforming Growth Factor beta Type I Receptor and Activin Type IB/IC Receptors