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    Glp1r glucagon-like peptide 1 receptor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25051, updated on 9-Dec-2024

    Summary

    Official Symbol
    Glp1rprovided by RGD
    Official Full Name
    glucagon-like peptide 1 receptorprovided by RGD
    Primary source
    RGD:2703
    See related
    EnsemblRapid:ENSRNOG00000001152 AllianceGenome:RGD:2703
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Glip; RATGL1RCP
    Summary
    Enables glucagon-like peptide 1 receptor activity and peptide hormone binding activity. Involved in several processes, including cAMP/PKA signal transduction; learning or memory; and positive regulation of insulin secretion. Located in plasma membrane. Used to study hyperglycemia and hypertension. Biomarker of obesity. Human ortholog(s) of this gene implicated in obesity. Orthologous to human GLP1R (glucagon like peptide 1 receptor). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 72.1) See more
    Orthologs
    NEW
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    Genomic context

    See Glp1r in Genome Data Viewer
    Location:
    20p12
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (8973393..9011622)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (8972004..9010241)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (9586075..9626228)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene dynein, axonemal, heavy chain 8 Neighboring gene U6 spliceosomal RNA Neighboring gene eukaryotic translation initiation factor 3, subunit I, pseudogene 4 Neighboring gene uncharacterized LOC134483876 Neighboring gene uromodulin-like 1 Neighboring gene uncharacterized LOC134483780 Neighboring gene small nucleolar RNA SNORA48

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein-coupled peptide receptor activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables G protein-coupled receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables glucagon receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables glucagon receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables glucagon-like peptide 1 receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables glucagon-like peptide 1 receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables glucagon-like peptide 1 receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables glucagon-like peptide 1 receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables peptide hormone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables peptide hormone binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables peptide receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in associative learning IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cAMP/PKA signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to glucagon stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in feeding behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in hormone secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in hormone secretion IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within_positive_effect hormone secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in insulin secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in learning or memory IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in learning or memory IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in learning or memory ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in memory IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of blood pressure IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of negative regulation of blood pressure ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of neuron apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in neuropeptide signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    NOT involved_in positive regulation of D-glucose import IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of blood pressure IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of blood pressure IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of blood pressure IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of blood pressure ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of insulin secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in post-translational protein targeting to membrane, translocation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within post-translational protein targeting to membrane, translocation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of calcium ion transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of heart contraction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of heart contraction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in release of sequestered calcium ion into cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to glucose IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to psychosocial stress IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to psychosocial stress ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    glucagon-like peptide 1 receptor
    Names
    GLP-1 receptor
    GLP-1-R
    GLP-1R
    pancreatic beta cell receptor for the gluco-incretin hormone glucagon-like peptide 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012728.2NP_036860.2  glucagon-like peptide 1 receptor precursor

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000020
      UniProtKB/Swiss-Prot
      P32301, Q64073, Q6LD83
      UniProtKB/TrEMBL
      F1LRH2
      Related
      ENSRNOP00000001527.5, ENSRNOT00000001527.8
      Conserved Domains (2) summary
      cd15268
      Location:141419
      7tmB1_GLP1R; glucagon-like peptide-1 receptor, member of the class B family of seven-transmembrane G protein-coupled receptors
      pfam02793
      Location:59128
      HRM; Hormone receptor domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      8973393..9011622
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)