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    Golga1 golgin A1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311919, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Golga1provided by RGD
    Official Full Name
    golgin A1provided by RGD
    Primary source
    RGD:1311305
    See related
    EnsemblRapid:ENSRNOG00000014493 AllianceGenome:RGD:1311305
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be located in perinuclear region of cytoplasm and trans-Golgi network. Predicted to be active in Golgi apparatus. Orthologous to human GOLGA1 (golgin A1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 72.3), Kidney (RPKM 71.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Golga1 in Genome Data Viewer
    Location:
    3q12
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (43175400..43222319, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (22765690..22812637, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (23309318..23353439, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA79 Neighboring gene WD repeat domain 38 Neighboring gene ribosomal protein L35 Neighboring gene actin related protein 2/3 complex, subunit 5-like Neighboring gene uncharacterized LOC134486089 Neighboring gene suppressor of cancer cell invasion like 1 Neighboring gene suppressor of cancer cell invasion

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The trans-Golgi network golgin, GCC185, is required for endosome-to-Golgi transport and maintenance of Golgi structure. Derby MC, et al. Traffic, 2007 Jun. PMID 17488291
    2. Murine CENPF interacts with syntaxin 4 in the regulation of vesicular transport. Pooley RD, et al. J Cell Sci, 2008 Oct 15. PMID 18827011, Free PMC Article
    3. Characterization of three paralogous members of the Mammalian vaccinia related kinase family. Nichols RJ, et al. J Biol Chem, 2004 Feb 27. PMID 14645249
    4. Loss-of-function mutations in TBC1D20 cause cataracts and male infertility in blind sterile mice and Warburg micro syndrome in humans. Liegel RP, et al. Am J Hum Genet, 2013 Dec 5. PMID 24239381, Free PMC Article
    5. Spatial regulation of Raf kinase signaling by RKTG. Feng L, et al. Proc Natl Acad Sci U S A, 2007 Sep 4. PMID 17724343, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    golgin subfamily A member 1
    Names
    Golgin subfamily A member 1
    golgi autoantigen, golgin subfamily a, 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395022.2 → NP_001381951.1  golgin subfamily A member 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I6A5T2, A6JEW1, D4A6K4
      Related
      ENSRNOP00000019703.4, ENSRNOT00000019703.7
      Conserved Domains (3) summary
      smart00755
      Location:683 → 728
      Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
      TIGR02168
      Location:151 → 497
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      NF033930
      Location:420 → 671
      pneumo_PspA; pneumococcal surface protein A

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      43175400..43222319 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039105298.2 → XP_038961226.1  golgin subfamily A member 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A5T2
      Conserved Domains (3) summary
      smart00755
      Location:545 → 590
      Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
      COG1196
      Location:223 → 544
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:13 → 359
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    RNA

    1. XR_010064647.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001107842.2: Suppressed sequence

      Description
      NM_001107842.2: This RefSeq was removed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein Strain
    Heading Accession and Version

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