Entpd7 ectonucleoside triphosphate diphosphohydrolase 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Entpd7provided by MGI
Official Full Name: ectonucleoside triphosphate diphosphohydrolase 7provided by MGI
Primary source: MGI:MGI:2135885
See related: Ensembl:ENSMUSG00000025192 AllianceGenome:MGI:2135885
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: LALP1; Lysal2; 1810012B13Rik; 1810020C02Rik; 2810003F23Rik
Summary: Enables ribonucleoside triphosphate phosphatase activity. Involved in T-helper 17 cell differentiation and regulation of immune response. Predicted to be located in cytoplasmic vesicle membrane and nucleus. Predicted to be active in Golgi apparatus and membrane. Orthologous to human ENTPD7 (ectonucleoside triphosphate diphosphohydrolase 7). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in large intestine adult (RPKM 10.3), duodenum adult (RPKM 9.0) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 C3; 19 36.67 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (43678128..43722292)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (43689689..43733853)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ENTPDase7 controls the luminal ATP level and, thereby, regulates Th17 cell development in the small intestine.
Title: Ecto-nucleoside triphosphate diphosphohydrolase 7 controls Th17 cell responses through regulation of luminal ATP in the small intestine.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1) 1 citation

General gene information

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Markers

NoName (e-PCR)
- UniSTS:237946

NoName (e-PCR)
- UniSTS:237947

NoName (e-PCR)
- UniSTS:237948

NoName (e-PCR)
- UniSTS:237950

NoName (e-PCR)
- UniSTS:237951

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent H2AZ histone chaperone activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent H3-H4 histone complex chaperone activity	IEA Inferred from Electronic Annotation more info
enables CTPase activity	ISO Inferred from Sequence Orthology more info
enables CTPase activity	ISS Inferred from Sequence or Structural Similarity more info
enables DNA clamp loader activity	IEA Inferred from Electronic Annotation more info
enables GDP phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	ISO Inferred from Sequence Orthology more info
enables GTPase activity	ISS Inferred from Sequence or Structural Similarity more info
enables UDP phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin extrusion motor activity	IEA Inferred from Electronic Annotation more info
enables cohesin loader activity	IEA Inferred from Electronic Annotation more info
enables membrane scission GTPase motor activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleoside diphosphate phosphatase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables ribonucleoside triphosphate phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ribonucleoside triphosphate phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables ribonucleoside triphosphate phosphatase activity	ISO Inferred from Sequence Orthology more info	PubMed

Process	Evidence Code	Pubs
involved_in CTP catabolic process	ISO Inferred from Sequence Orthology more info
involved_in CTP catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in CTP metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in GTP metabolic process	ISO Inferred from Sequence Orthology more info
involved_in GTP metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in T-helper 17 cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in UDP catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in UTP catabolic process	ISO Inferred from Sequence Orthology more info
involved_in UTP catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in chromatin looping	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in nucleobase-containing small molecule catabolic process	ISO Inferred from Sequence Orthology more info
involved_in nucleobase-containing small molecule catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of immune response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ribonucleoside diphosphate catabolic process	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within ribonucleoside triphosphate catabolic process	ISO Inferred from Sequence Orthology more info	PubMed

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic vesicle membrane	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: ectonucleoside triphosphate diphosphohydrolase 7

Names: NTPDase 7; lysosomal apyrase-like 2; lysosomal apyrase-like protein 1

NP_444333.3

EC 3.6.1.15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.