Egfl7 EGF-like-domain, multiple 7 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Egfl7provided by RGD
Official Full Name: EGF-like-domain, multiple 7provided by RGD
Primary source: RGD:708507
See related: EnsemblRapid:ENSRNOG00000019388 AllianceGenome:RGD:708507
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable Notch binding activity. Predicted to be involved in vasculogenesis. Predicted to act upstream of or within negative regulation of Notch signaling pathway; negative regulation of smooth muscle cell migration; and positive regulation of endothelial cell proliferation. Predicted to be located in extracellular space. Predicted to be active in cell surface and extracellular region. Orthologous to human EGFL7 (EGF like domain multiple 7). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Lung (RPKM 876.4), Heart (RPKM 373.5) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3p13

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (29802481..29814966)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (9404622..9416879)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (4034759..4044280)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The mechanism of EGFL7 regulating neovascularization in diabetic retinopathy through the PI3K/AKT/VEGFA pathway.
Title: The mechanism of EGFL7 regulating neovascularization in diabetic retinopathy through the PI3K/AKT/VEGFA pathway.
Data show that Astragalus polysaccharides reduce airway remodeling and alveolar damage by upregulating the expression of epidermal growth factor-like domains protein 7 (EGFL7) and exert protective effects against dysplasia in neonatal rats.
Title: Astragalus polysaccharides exert protective effects in newborn rats with bronchopulmonary dysplasia by upregulating the expression of EGFL7 in lung tissue.

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General gene information

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Markers

RH141414 (e-PCR)
- UniSTS:223408

RH141422 (e-PCR)
- UniSTS:223416

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables Notch binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in blood vessel development	ISO Inferred from Sequence Orthology more info
involved_in blood vessel development	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of Notch signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of Notch signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of smooth muscle cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of smooth muscle cell migration	ISO Inferred from Sequence Orthology more info
involved_in vasculogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in vasculogenesis	ISO Inferred from Sequence Orthology more info
involved_in vasculogenesis	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular region	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info
located_in extracellular region	ISS Inferred from Sequence or Structural Similarity more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: epidermal growth factor-like protein 7

Names: EGF-like domain 7; EGF-like domain-containing protein 7; EGF-like protein 7; Estrogen-regulated protein CBL20, 20.4kD; multiple EGF-like domain protein 7; multiple EGF-like domains protein 7; multiple epidermal growth factor-like domain protein 7; multiple epidermal growth factor-like domains protein 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001399187.1 → NP_001386116.1 epidermal growth factor-like protein 7 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A0A8L2QF53, A6JTF9

Related

ENSRNOP00000026318.6, ENSRNOT00000026318.8

Conserved Domains (2) summary

pfam07645
Location:145 → 184

EGF_CA; Calcium-binding EGF domain

pfam07546
Location:32 → 101

EMI; EMI domain
NM_001399188.1 → NP_001386117.1 epidermal growth factor-like protein 7 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A0A8L2QF53, A6JTF9

Related

ENSRNOP00000088876.2, ENSRNOT00000107620.2

Conserved Domains (2) summary

pfam07645
Location:145 → 184

EGF_CA; Calcium-binding EGF domain

pfam07546
Location:32 → 101

EMI; EMI domain

RNA

NR_174164.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

29802481..29814966

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039104248.2 → XP_038960176.1 epidermal growth factor-like protein 7 isoform X1

UniProtKB/Swiss-Prot

Q6AZ60, Q9JKW3

UniProtKB/TrEMBL

A0A8L2QF53, A6JTF9

Related

ENSRNOP00000081631.2, ENSRNOT00000115008.2

Conserved Domains (2) summary

pfam07645
Location:145 → 184

EGF_CA; Calcium-binding EGF domain

pfam07546
Location:32 → 101

EMI; EMI domain