Sdhaf2 succinate dehydrogenase complex assembly factor 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Sdhaf2provided by RGD
Official Full Name: succinate dehydrogenase complex assembly factor 2provided by RGD
Primary source: RGD:1309216
See related: EnsemblRapid:ENSRNOG00000020646 AllianceGenome:RGD:1309216
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1309216
Summary: Predicted to be involved in aerobic respiration; mitochondrial respiratory chain complex II assembly; and protein-FAD linkage. Predicted to act upstream of or within negative regulation of canonical Wnt signaling pathway; negative regulation of epithelial to mesenchymal transition; and protein dephosphorylation. Predicted to be located in cytosol and nucleolus. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in paraganglioma. Orthologous to human SDHAF2 (succinate dehydrogenase complex assembly factor 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Heart (RPKM 258.3), Muscle (RPKM 236.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q43

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (216564002..216592877, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (207139070..207167830, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (226543671..226572414, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SDH5 down-regulation mitigates the damage of osteoporosis via inhibiting the MyD88/NF-kappaB signaling pathway.
Title: SDH5 down-regulation mitigates the damage of osteoporosis via inhibiting the MyD88/NF-κB signaling pathway.

Submit: New GeneRIF Correction

General gene information

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Markers

RH129510 (e-PCR)
- UniSTS:212813

AW521848 (e-PCR)
- UniSTS:249725

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
acts_upstream_of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial electron transport, succinate to ubiquinone	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial electron transport, succinate to ubiquinone	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial electron transport, succinate to ubiquinone	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial electron transport, succinate to ubiquinone	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitochondrial respiratory chain complex II assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial respiratory chain complex II assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein dephosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein-FAD linkage	ISO Inferred from Sequence Orthology more info
involved_in protein-FAD linkage	ISS Inferred from Sequence or Structural Similarity more info
involved_in tricarboxylic acid cycle	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: succinate dehydrogenase assembly factor 2, mitochondrial

Names: SDH assembly factor 2; succinate dehydrogenase subunit 5, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001008371.1 → NP_001008372.1 succinate dehydrogenase assembly factor 2, mitochondrial precursor

See identical proteins and their annotated locations for NP_001008372.1

Status: PROVISIONAL

Source sequence(s)

BC086542

UniProtKB/Swiss-Prot

Q5RJQ7

UniProtKB/TrEMBL

A0A8I6AIT7, A6I035

Related

ENSRNOP00000094094.1, ENSRNOT00000099357.2

Conserved Domains (1) summary

pfam03937
Location:65 → 138

Sdh5; Flavinator of succinate dehydrogenase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

216564002..216592877 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017589442.3 → XP_017444931.1 succinate dehydrogenase assembly factor 2, mitochondrial isoform X3

UniProtKB/TrEMBL

A0A8I5ZL70

Conserved Domains (1) summary

pfam03937
Location:65 → 122

Sdh5; Flavinator of succinate dehydrogenase
XM_039084172.2 → XP_038940100.1 succinate dehydrogenase assembly factor 2, mitochondrial isoform X4

UniProtKB/TrEMBL

A0A8I5ZL70

Conserved Domains (1) summary

pfam03937
Location:65 → 122

Sdh5; Flavinator of succinate dehydrogenase
XM_063268386.1 → XP_063124456.1 succinate dehydrogenase assembly factor 2, mitochondrial isoform X6
XM_006231042.3 → XP_006231104.1 succinate dehydrogenase assembly factor 2, mitochondrial isoform X2

UniProtKB/TrEMBL

A0A8I6AIT7

Related

ENSRNOP00000028028.5, ENSRNOT00000028028.6

Conserved Domains (1) summary

pfam03937
Location:55 → 128

Sdh5; Flavinator of succinate dehydrogenase
XM_063268380.1 → XP_063124450.1 succinate dehydrogenase assembly factor 2, mitochondrial isoform X5
XM_063268376.1 → XP_063124446.1 succinate dehydrogenase assembly factor 2, mitochondrial isoform X3

Related

ENSRNOP00000093612.1, ENSRNOT00000100064.2
XM_063268367.1 → XP_063124437.1 succinate dehydrogenase assembly factor 2, mitochondrial isoform X1

Related

ENSRNOP00000101688.1, ENSRNOT00000129174.1