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    Extl2 exostosin-like glycosyltransferase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 310803, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Extl2provided by RGD
    Official Full Name
    exostosin-like glycosyltransferase 2provided by RGD
    Primary source
    RGD:1307684
    See related
    EnsemblRapid:ENSRNOG00000014323 AllianceGenome:RGD:1307684
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including acetylgalactosaminyltransferase activity; glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity; and manganese ion binding activity. Predicted to be involved in N-acetylglucosamine metabolic process and UDP-N-acetylgalactosamine metabolic process. Predicted to be located in cytosol; endoplasmic reticulum; and nucleoplasm. Orthologous to human EXTL2 (exostosin like glycosyltransferase 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 126.3), Muscle (RPKM 34.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Extl2 in Genome Data Viewer
    Location:
    2q42
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (206607106..206631861)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (203922217..203946940)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (218951112..218972576)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene diphthamide biosynthesis 5 Neighboring gene solute carrier family 30 member 7 Neighboring gene uncharacterized LOC120100923 Neighboring gene ribosomal protein L13, pseudogene 18 Neighboring gene ribosomal protein S27a, pseudogene 24

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Crystal structure of an alpha 1,4-N-acetylhexosaminyltransferase (EXTL2), a member of the exostosin gene family involved in heparan sulfate biosynthesis. Pedersen LC, et al. J Biol Chem, 2003 Apr 18. PMID 12562774
    2. The tumor suppressor EXT-like gene EXTL2 encodes an alpha1, 4-N-acetylhexosaminyltransferase that transfers N-acetylgalactosamine and N-acetylglucosamine to the common glycosaminoglycan-protein linkage region. The key enzyme for the chain initiation of heparan sulfate. Kitagawa H, et al. J Biol Chem, 1999 May 14. PMID 10318803
    3. The putative tumor suppressors EXT1 and EXT2 form a stable complex that accumulates in the Golgi apparatus and catalyzes the synthesis of heparan sulfate. McCormick C, et al. Proc Natl Acad Sci U S A, 2000 Jan 18. PMID 10639137, Free PMC Article
    4. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables alpha-1,4-N-acetylgalactosaminyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glycosaminoglycan binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables manganese ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in N-acetylglucosamine metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in UDP-N-acetylgalactosamine metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    exostosin-like 2
    Names
    exostoses (multiple)-like 2
    exostoses-like 2
    exotoses (multiple)-like 2
    NP_001094174.1
    XP_006233277.1
    XP_006233278.1
    XP_038958355.1
    XP_038958356.1
    XP_063138002.1
    XP_063138003.1
    XP_063138004.1
    XP_063138005.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100704.1 → NP_001094174.1  exostosin-like 2

      See identical proteins and their annotated locations for NP_001094174.1

      Status: PROVISIONAL

      Source sequence(s)
      BC162014
      UniProtKB/TrEMBL
      B1WC59, F7F8T0
      Conserved Domains (1) summary
      pfam09258
      Location:66 → 312
      Glyco_transf_64; Glycosyl transferase family 64 domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      206607106..206631861
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006233216.5 → XP_006233278.1  exostosin-like 2 isoform X1

      See identical proteins and their annotated locations for XP_006233278.1

      UniProtKB/TrEMBL
      B1WC59, F7F8T0
      Related
      ENSRNOP00000019190.5, ENSRNOT00000019190.7
      Conserved Domains (1) summary
      pfam09258
      Location:66 → 312
      Glyco_transf_64; Glycosyl transferase family 64 domain

    2. XM_063281935.1 → XP_063138005.1  exostosin-like 2 isoform X3

    3. XM_039102428.2 → XP_038958356.1  exostosin-like 2 isoform X2

      UniProtKB/TrEMBL
      F7F8T0
      Conserved Domains (1) summary
      pfam09258
      Location:49 → 279
      Glyco_transf_64; Glycosyl transferase family 64 domain

    4. XM_063281933.1 → XP_063138003.1  exostosin-like 2 isoform X3

    5. XM_039102427.2 → XP_038958355.1  exostosin-like 2 isoform X2

      UniProtKB/TrEMBL
      F7F8T0
      Conserved Domains (1) summary
      pfam09258
      Location:49 → 279
      Glyco_transf_64; Glycosyl transferase family 64 domain

    6. XM_063281934.1 → XP_063138004.1  exostosin-like 2 isoform X3

    7. XM_063281932.1 → XP_063138002.1  exostosin-like 2 isoform X2

    8. XM_006233215.5 → XP_006233277.1  exostosin-like 2 isoform X1

      See identical proteins and their annotated locations for XP_006233277.1

      UniProtKB/TrEMBL
      B1WC59, F7F8T0
      Conserved Domains (1) summary
      pfam09258
      Location:66 → 312
      Glyco_transf_64; Glycosyl transferase family 64 domain
    Nucleotide Protein Strain
    Heading Accession and Version

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