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    Pnliprp1 pancreatic lipase-related protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 84028, updated on 27-Nov-2024

    Summary

    Official Symbol
    Pnliprp1provided by RGD
    Official Full Name
    pancreatic lipase-related protein 1provided by RGD
    Primary source
    RGD:620792
    See related
    EnsemblRapid:ENSRNOG00000017908 AllianceGenome:RGD:620792
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables lipase activity. Involved in pancreas development; response to glucocorticoid; and response to peptide hormone. Located in extracellular space. Orthologous to human PNLIPRP1 (pancreatic lipase related protein 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Spleen (RPKM 3818.0) and Liver (RPKM 1444.6) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Pnliprp1 in Genome Data Viewer
    Location:
    1q55
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (267854027..267869654)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (257867885..257883514)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (279867034..279882663)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 172 Neighboring gene pancreatic lipase Neighboring gene pancreatic lipase related protein 2 Neighboring gene sperm microtubule inner protein 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables calcium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables lipase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT enables lipase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables lipoprotein lipase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phospholipase A1 activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables triacylglycerol lipase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in cholesterol homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in fatty acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in high-density lipoprotein particle remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in pancreas development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to glucocorticoid IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to peptide hormone IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in triglyceride catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    inactive pancreatic lipase-related protein 1
    Names
    PL-RP1
    NP_114470.1
    XP_063131831.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_032081.1NP_114470.1  inactive pancreatic lipase-related protein 1 precursor

      See identical proteins and their annotated locations for NP_114470.1

      Status: PROVISIONAL

      Source sequence(s)
      X61925
      UniProtKB/Swiss-Prot
      P54316
      UniProtKB/TrEMBL
      A6JI67, G3V8A9
      Related
      ENSRNOP00000024164.4, ENSRNOT00000024164.6
      Conserved Domains (2) summary
      cd01759
      Location:356467
      PLAT_PL; PLAT/LH2 domain of pancreatic triglyceride lipase. Lipases hydrolyze phospholipids and triglycerides to generate fatty acids for energy production or for storage and to release inositol phosphates that act as second messengers. The central role of ...
      pfam00151
      Location:18353
      Lipase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      267854027..267869654
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063275761.1XP_063131831.1  inactive pancreatic lipase-related protein 1 isoform X1