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    Id1 inhibitor of DNA binding 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25261, updated on 27-Nov-2024

    Summary

    Official Symbol
    Id1provided by RGD
    Official Full Name
    inhibitor of DNA binding 1provided by RGD
    Primary source
    RGD:2858
    See related
    EnsemblRapid:ENSRNOG00000021750 AllianceGenome:RGD:2858
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Idb1; ID125A
    Summary
    Enables identical protein binding activity and proteasome binding activity. Involved in several processes, including cell-abiotic substrate adhesion; negative regulation of cell differentiation; and regulation of gene expression. Located in centrosome. Used to study pulmonary hypertension. Biomarker of cholestasis. Orthologous to human ID1 (inhibitor of DNA binding 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Lung (RPKM 290.4), Heart (RPKM 137.4) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Id1 in Genome Data Viewer
    Location:
    3q41
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (161671525..161672691)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (141210666..141212420)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (148214623..148216715)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102553281 Neighboring gene RRAD and GEM like GTPase 1 Neighboring gene histocompatibility minor 13 Neighboring gene MCTS family member 2 Neighboring gene uncharacterized LOC134486187 Neighboring gene uncharacterized LOC134486188 Neighboring gene cytochrome c oxidase subunit 4i2 Neighboring gene Bcl2-like 1 Neighboring gene ribosomal protein S2, pseudogene 43

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC156482

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables proteasome binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transcription regulator inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transcription regulator inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within BMP signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell-abiotic substrate adhesion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to dopamine IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to epidermal growth factor stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to nerve growth factor stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to peptide IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to transforming growth factor beta stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in circadian rhythm ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within collagen metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of endothelial cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within endothelial cell morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within heart development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within lung morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within lung vasculature development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cold-induced thermogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cold-induced thermogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in negative regulation of dendrite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of endothelial cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of endothelial cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of osteoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuron differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in neuron differentiation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in positive regulation of actin filament bundle assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of epithelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein destabilization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of vasculature development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within response to antibiotic ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to organic cyclic compound IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    DNA-binding protein inhibitor ID-1
    Names
    Inhibitor of DNA binding 1 helix-loop-helix protein (splice varaiation)
    Inhibitor of DNA binding 1, helix-loop-helix protein (splice variation)
    inhibitor of DNA binding 1, HLH protein
    inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
    inhibitor of differentiation 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012797.2NP_036929.2  DNA-binding protein inhibitor ID-1

      See identical proteins and their annotated locations for NP_036929.2

      Status: VALIDATED

      Source sequence(s)
      AI073271, M86708
      UniProtKB/Swiss-Prot
      P41135
      UniProtKB/TrEMBL
      A0JPJ2, A6KHQ6
      Conserved Domains (1) summary
      cd19691
      Location:55106
      bHLH_dnHLH_ID1; basic helix-loop-helix (bHLH) domain found in DNA-binding protein inhibitor ID1 and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      161671525..161672691
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006235267.5XP_006235329.1  DNA-binding protein inhibitor ID-1 isoform X1

      UniProtKB/Swiss-Prot
      P41135
      UniProtKB/TrEMBL
      A0A8L2QPI3, A6KHQ6
      Related
      ENSRNOP00000052261.3, ENSRNOT00000029660.7
      Conserved Domains (1) summary
      cd19691
      Location:55106
      bHLH_dnHLH_ID1; basic helix-loop-helix (bHLH) domain found in DNA-binding protein inhibitor ID1 and similar proteins