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    Gfra2 GDNF family receptor alpha 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25136, updated on 9-Dec-2024

    Summary

    Official Symbol
    Gfra2provided by RGD
    Official Full Name
    GDNF family receptor alpha 2provided by RGD
    Primary source
    RGD:61809
    See related
    EnsemblRapid:ENSRNOG00000014010 AllianceGenome:RGD:61809
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Retl2
    Summary
    Enables glial cell-derived neurotrophic factor receptor activity. Involved in negative regulation of protein autophosphorylation. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane. Biomarker of Parkinsonism. Orthologous to human GFRA2 (GDNF family receptor alpha 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 77.1), Lung (RPKM 66.4) and 7 other tissues See more
    Orthologs
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    Genomic context

    See Gfra2 in Genome Data Viewer
    Location:
    15p11
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (52351499..52443369)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (45941841..46033715)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (52557004..52648984)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482146 Neighboring gene nucleophosmin/nucleoplasmin 2 Neighboring gene exportin 7 Neighboring gene docking protein 2 Neighboring gene 60S ribosomal protein L31-like Neighboring gene uncharacterized LOC134482147

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    GDNF family receptor alpha-2
    Names
    glial cell line derived neurotrophic factor family receptor alpha 2
    tyrosine kinase receptor ligand 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012750.2NP_036882.1  GDNF family receptor alpha-2

      See identical proteins and their annotated locations for NP_036882.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      A6HTN1, F7FQ45, O35977, Q792X9
      Related
      ENSRNOP00000019222.2, ENSRNOT00000019222.5
      Conserved Domains (2) summary
      smart00907
      Location:40113
      GDNF; GDNF/GAS1 domain
      pfam02351
      Location:251347
      GDNF; GDNF/GAS1 domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      52351499..52443369
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017599582.3XP_017455071.1  GDNF family receptor alpha-2 isoform X1

    2. XM_017599583.3XP_017455072.1  GDNF family receptor alpha-2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A8G6
      Related
      ENSRNOP00000088757.1, ENSRNOT00000094535.2