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    Acsl5 acyl-CoA synthetase long-chain family member 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 94340, updated on 3-Dec-2024

    Summary

    Official Symbol
    Acsl5provided by RGD
    Official Full Name
    acyl-CoA synthetase long-chain family member 5provided by RGD
    Primary source
    RGD:69402
    See related
    EnsemblRapid:ENSRNOG00000016265 AllianceGenome:RGD:69402
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Acs5; Facl5
    Summary
    Enables arachidonate-CoA ligase activity. Involved in several processes, including organophosphate biosynthetic process; positive regulation of lipid metabolic process; and positive regulation of long-chain fatty acid import across plasma membrane. Predicted to be located in nucleolus; nucleoplasm; and plasma membrane. Predicted to be active in endoplasmic reticulum; membrane; and mitochondrion. Human ortholog(s) of this gene implicated in congenital diarrhea. Orthologous to human ACSL5 (acyl-CoA synthetase long chain family member 5). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Liver (RPKM 1524.8), Lung (RPKM 491.8) and 8 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Acsl5 in Genome Data Viewer
    Location:
    1q55
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (264294851..264341943)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (254289513..254336608)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (276240703..276290012)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene extensin-like Neighboring gene glycerol-3-phosphate acyltransferase, mitochondrial Neighboring gene tectorin beta Neighboring gene guanylate cyclase 2G Neighboring gene zinc finger DHHC-type palmitoyltransferase 6 Neighboring gene vesicle transport through interaction with t-SNAREs 1A Neighboring gene uncharacterized LOC134485256 Neighboring gene uncharacterized LOC134485255

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables arachidonate-CoA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables arachidonate-CoA ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables long-chain fatty acid-CoA ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables long-chain fatty acid-CoA ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables long-chain fatty acid-CoA ligase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables long-chain fatty acid-CoA ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables oleoyl-CoA ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables oleoyl-CoA ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables oleoyl-CoA ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in cellular response to insulin stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in fatty acid metabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in fatty acid transport IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in lipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in long-chain fatty acid metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in long-chain fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in long-chain fatty acid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in long-chain fatty acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in long-chain fatty-acyl-CoA biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in long-chain fatty-acyl-CoA biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in phospholipid biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of fatty acid beta-oxidation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of long-chain fatty acid import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of long-chain fatty acid import across plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of triglyceride biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of extrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to cholesterol IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to glucose IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to nutrient IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to sucrose IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    long-chain-fatty-acid--CoA ligase 5
    Names
    LACS 5
    arachidonate--CoA ligase
    fatty acid Coenzyme A ligase, long chain 5
    long-chain acyl-CoA synthetase 5
    long-chain fatty acid coenzyme A ligase 5
    NP_446059.2
    XP_038949085.1
    XP_038949096.1
    XP_038949101.1
    XP_038949105.1
    XP_063132073.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053607.2NP_446059.2  long-chain-fatty-acid--CoA ligase 5

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      O88813
      UniProtKB/TrEMBL
      A6JHY8, A6JHY9, Q6IN15
      Related
      ENSRNOP00000078386.1, ENSRNOT00000109824.2
      Conserved Domains (1) summary
      cd05927
      Location:101678
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      264294851..264341943
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063276003.1XP_063132073.1  long-chain-fatty-acid--CoA ligase 5 isoform X4

      UniProtKB/Swiss-Prot
      O88813
      Related
      ENSRNOP00000080415.2, ENSRNOT00000110033.2
    2. XM_039093168.2XP_038949096.1  long-chain-fatty-acid--CoA ligase 5 isoform X1

      UniProtKB/Swiss-Prot
      O88813
      UniProtKB/TrEMBL
      A6JHY8, A6JHY9, Q6IN15
      Conserved Domains (1) summary
      cd05927
      Location:101678
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
    3. XM_039093157.2XP_038949085.1  long-chain-fatty-acid--CoA ligase 5 isoform X1

      UniProtKB/Swiss-Prot
      O88813
      UniProtKB/TrEMBL
      A6JHY8, A6JHY9, Q6IN15
      Related
      ENSRNOP00000022126.8, ENSRNOT00000022126.8
      Conserved Domains (1) summary
      cd05927
      Location:101678
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
    4. XM_039093177.2XP_038949105.1  long-chain-fatty-acid--CoA ligase 5 isoform X3

      UniProtKB/Swiss-Prot
      O88813
      Conserved Domains (1) summary
      cd05927
      Location:78655
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
    5. XM_039093173.2XP_038949101.1  long-chain-fatty-acid--CoA ligase 5 isoform X2

      UniProtKB/Swiss-Prot
      O88813
      Conserved Domains (1) summary
      cd05927
      Location:96673
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)