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    Fgf17 fibroblast growth factor 17 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29368, updated on 27-Nov-2024

    Summary

    Official Symbol
    Fgf17provided by RGD
    Official Full Name
    fibroblast growth factor 17provided by RGD
    Primary source
    RGD:2607
    See related
    EnsemblRapid:ENSRNOG00000012912 AllianceGenome:RGD:2607
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Fgf6b
    Summary
    Predicted to enable growth factor activity; type 1 fibroblast growth factor receptor binding activity; and type 2 fibroblast growth factor receptor binding activity. Predicted to be involved in several processes, including fibroblast growth factor receptor signaling pathway; positive regulation of MAPK cascade; and positive regulation of cell population proliferation. Predicted to be active in cytoplasm and extracellular space. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 20 with or without anosmia. Orthologous to human FGF17 (fibroblast growth factor 17). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
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    Genomic context

    See Fgf17 in Genome Data Viewer
    Location:
    15p11
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (52118141..52132083, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (45711498..45717622, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (52326758..52337360, complement)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene FHF complex subunit HOOK interacting protein 2B Neighboring gene dematin actin binding protein Neighboring gene uncharacterized LOC134482146 Neighboring gene nucleophosmin/nucleoplasmin 2 Neighboring gene exportin 7 Neighboring gene docking protein 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables growth factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables type 1 fibroblast growth factor receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables type 1 fibroblast growth factor receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables type 1 fibroblast growth factor receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables type 2 fibroblast growth factor receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables type 2 fibroblast growth factor receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables type 2 fibroblast growth factor receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    fibroblast growth factor 17
    Names
    FGF-17
    fibroblast growth factor 6b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001411948.1NP_001398877.1  fibroblast growth factor 17 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
    2. NM_019198.2NP_062071.1  fibroblast growth factor 17 isoform 1 precursor

      See identical proteins and their annotated locations for NP_062071.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/Swiss-Prot
      P63076
      UniProtKB/TrEMBL
      A0A8I5ZML6, A6HTM4
      Related
      ENSRNOP00000098977.1, ENSRNOT00000128915.1
      Conserved Domains (1) summary
      pfam00167
      Location:53175
      FGF; Fibroblast growth factor

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      52118141..52132083 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063274180.1XP_063130250.1  fibroblast growth factor 17 isoform X1

      Related
      ENSRNOP00000101324.1, ENSRNOT00000168789.1