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    CG7656 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39691, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG7656provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036516
    Locus tag
    Dmel_CG7656
    See related
    AllianceGenome:FB:FBgn0036516
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG7656
    Summary
    Predicted to enable ubiquitin conjugating enzyme activity. Predicted to be involved in protein K48-linked ubiquitination and ubiquitin-dependent protein catabolic process. Is expressed in central brain primordium; embryonic brain; organism; and ventral nerve cord primordium. Orthologous to human CDC34 (cell division cycle 34, ubiqiutin conjugating enzyme) and UBE2R2 (ubiquitin conjugating enzyme E2 R2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG7656 in Genome Data Viewer
    Location:
    71E1-71E1; 3-43 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (15585431..15588175, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (15578531..15581275, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene aaRS-interacting multifunctional protein 2 Neighboring gene Rho GTPase activating protein at 71E Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of factors that function in Drosophila salivary gland cell death during development using proteomics. McPhee CK, et al. Cell Death Differ, 2013 Feb. PMID 22935612, Free PMC Article
    2. Functional and phylogenetic analysis of the ubiquitylation system in Caenorhabditis elegans: ubiquitin-conjugating enzymes, ubiquitin-activating enzymes, and ubiquitin-like proteins. Jones D, et al. Genome Biol, 2002. PMID 11806825, Free PMC Article
    3. What was the set of ubiquitin and ubiquitin-like conjugating enzymes in the eukaryote common ancestor? Michelle C, et al. J Mol Evol, 2009 Jun. PMID 19452197, Free PMC Article
    4. A novel strategy to isolate ubiquitin conjugates reveals wide role for ubiquitination during neural development. Franco M, et al. Mol Cell Proteomics, 2011 May. PMID 20861518, Free PMC Article
    5. The BEAF insulator regulates genes involved in cell polarity and neoplastic growth. Gurudatta BV, et al. Dev Biol, 2012 Sep 1. PMID 22743648, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ubiquitin conjugating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin conjugating enzyme activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein K48-linked ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein polyubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG7656-PA
    CG7656-PD
    CG7656-PE
    CG7656-PF
    NP_001261885.1
    NP_648783.4
    NP_730058.2
    NP_730059.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      15585431..15588175 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274956.1 → NP_001261885.1  uncharacterized protein Dmel_CG7656, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261885.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NN25, Q8IQM5
      Conserved Domains (2) summary
      COG5078
      Location:45 → 182
      COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
      cd00195
      Location:42 → 186
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    2. NM_168628.3 → NP_730059.1  uncharacterized protein Dmel_CG7656, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730059.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NN25, Q8IQM5
      Related
      FBpp0075345
      Conserved Domains (2) summary
      COG5078
      Location:45 → 182
      COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
      cd00195
      Location:42 → 186
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    3. NM_168627.3 → NP_730058.2  uncharacterized protein Dmel_CG7656, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730058.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      D0IQC8, Q6NN25, Q8IQM4, Q9VUR4
      Conserved Domains (2) summary
      COG5078
      Location:45 → 182
      COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
      cd00195
      Location:42 → 186
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    4. NM_140526.5 → NP_648783.4  uncharacterized protein Dmel_CG7656, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648783.4

      Status: REVIEWED

      UniProtKB/TrEMBL
      D0IQC8, Q6NN25, Q8IQM4, Q9VUR4
      Conserved Domains (2) summary
      COG5078
      Location:45 → 182
      COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
      cd00195
      Location:42 → 186
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6AWG5 Q6AWG5
    Q8IQM5 Q8IQM5
    Q960Q5 Q960Q5
    Q9VUR4 Q9VUR4

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