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    CG4424 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42390, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG4424provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038765
    Locus tag
    Dmel_CG4424
    See related
    AllianceGenome:FB:FBgn0038765
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG4424
    Summary
    Predicted to enable DNA-binding transcription factor activity and transcription cis-regulatory region binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. Is expressed in organism. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG4424 in Genome Data Viewer
    Location:
    92C1-92C1; 3-67 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (20026487..20028040, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (15852209..15853762, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Phosphatidylinositol glycan anchor biosynthesis class L Neighboring gene phagocyte signaling impaired Neighboring gene uncharacterized protein Neighboring gene trade embargo Neighboring gene identity crisis Neighboring gene Regnase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of germ plasm-enriched mRNAs in Drosophila melanogaster by the cDNA microarray technique. Szuperák M, et al. Gene Expr Patterns, 2005 Jun. PMID 15939385
    2. Twenty-seven ZAD-ZNF genes of Drosophila melanogaster are orthologous to the embryo polarity determining mosquito gene cucoid. Li M, et al. PLoS One, 2023. PMID 36595500, Free PMC Article
    3. Transcription profiling in Drosophila eyes that overexpress the human glaucoma-associated trabecular meshwork-inducible glucocorticoid response protein/myocilin (TIGR/MYOC). Borrás T, et al. Genetics, 2003 Feb. PMID 12618402, Free PMC Article
    4. An RNA-interference screen in Drosophila to identify ZAD-containing C2H2 zinc finger genes that function in female germ cells. Shapiro-Kulnane L, et al. G3 (Bethesda), 2021 Jan 18. PMID 33561227, Free PMC Article
    5. ZAD-Domain Is Essential for Nuclear Localization of Insulator Proteins in Drosophila melanogaster. Zolotarev NA, et al. Acta Naturae, 2016 Jul-Sep. PMID 27795848, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription cis-regulatory region binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG4424-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      20026487..20028040 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142602.3 → NP_650859.3  uncharacterized protein Dmel_CG4424 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650859.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T026, Q9VDQ6
      Related
      FBpp0083250
      Conserved Domains (5) summary
      COG5048
      Location:210 → 345
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:217 → 237
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam07776
      Location:10 → 92
      zf-AD; Zinc-finger associated domain (zf-AD)
      pfam13465
      Location:257 → 282
      zf-H2C2_2; Zinc-finger double domain
      cl19237
      Location:204 → 281
      DUF45; Protein of unknown function DUF45
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8T026 Q8T026
    Q9VDQ6 Q9VDQ6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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