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    lace lace [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34910, updated on 9-Dec-2024

    Summary

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    Official Symbol
    laceprovided by FlyBase
    Official Full Name
    laceprovided by FlyBase
    Primary source
    FLYBASE:FBgn0002524
    Locus tag
    Dmel_CG4162
    See related
    AllianceGenome:FB:FBgn0002524
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:Posey289; BG:DS01845.3; br36; CG4162; Dmel\CG4162; dSpt2; l(2)35Dc; l(2)br36; l35Dc; Lace; SPT; SPT-II; Spt2; SPTLC2
    Summary
    Enables serine C-palmitoyltransferase activity. Involved in imaginal disc development and sphingolipid biosynthetic process. Located in plasma membrane. Is expressed in several structures, including gut section; head; imaginal disc; and spermatozoon. Used to study hereditary sensory and autonomic neuropathy type 1. Human ortholog(s) of this gene implicated in hereditary sensory and autonomic neuropathy type 1C. Orthologous to human SPTLC2 (serine palmitoyltransferase long chain base subunit 2) and SPTLC3 (serine palmitoyltransferase long chain base subunit 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See lace in Genome Data Viewer
    Location:
    35D2-35D2; 2-51 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (15499127..15505018)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (15499127..15505018)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45293 Neighboring gene Translocase inner membrane 17 Neighboring gene long non-coding RNA:CR44864 Neighboring gene long non-coding RNA:CR43761

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ceramides Increase Fatty Acid Utilization in Intestinal Progenitors to Enhance Stemness and Increase Tumor Risk. Li Y, et al. Gastroenterology, 2023 Nov. PMID 37541526, Free PMC Article
    2. Identification and characterization by electrospray mass spectrometry of endogenous Drosophila sphingadienes. Fyrst H, et al. J Lipid Res, 2008 Mar. PMID 18156591
    3. Sphingolipids regulate neuromuscular synapse structure and function in Drosophila. West RJH, et al. J Comp Neurol, 2018 Sep 1. PMID 29761896, Free PMC Article
    4. Scutoid mutation of Drosophila melanogaster specifically decreases olfactory responses to short-chain acetate esters and ketones. Dubin AE, et al. J Neurobiol, 1995 Oct. PMID 8537826
    5. Identification of dietary alanine toxicity and trafficking dysfunction in a Drosophila model of hereditary sensory and autonomic neuropathy type 1. Oswald MC, et al. Hum Mol Genet, 2015 Dec 15. PMID 26395456, Free PMC Article

    See all (101) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine C-palmitoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine C-palmitoyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ceramide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in imaginal disc development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sphingolipid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sphingosine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in endomembrane system HDA PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of serine palmitoyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of serine palmitoyltransferase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    lace
    Names
    CG4162-PA
    CG4162-PB
    lace-PA
    lace-PB
    serine palmitoyl-transferase
    serine palmitoyltransferase subunit II
    sphingosine palmitoyl transferase
    NP_001285957.1
    NP_476614.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      15499127..15505018
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057266.5 → NP_476614.1  lace, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476614.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U912, Q9V3F2
      Related
      FBpp0080297
      Conserved Domains (2) summary
      PLN02483
      Location:117 → 587
      PLN02483; serine palmitoyltransferase
      COG0156
      Location:164 → 577
      BioF; 7-keto-8-aminopelargonate synthetase or related enzyme [Coenzyme transport and metabolism]

    2. NM_001299028.1 → NP_001285957.1  lace, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285957.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U912, Q9V3F2
      Conserved Domains (2) summary
      PLN02483
      Location:117 → 587
      PLN02483; serine palmitoyltransferase
      COG0156
      Location:164 → 577
      BioF; 7-keto-8-aminopelargonate synthetase or related enzyme [Coenzyme transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9U912 Q9U912
    Q9V3F2 Q9V3F2

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