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    SelT Selenoprotein T [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33725, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SelTprovided by FlyBase
    Official Full Name
    Selenoprotein Tprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031670
    Locus tag
    Dmel_CG3887
    See related
    AllianceGenome:FB:FBgn0031670
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3887; Dmel\CG3887; SELT
    Summary
    Predicted to enable thioredoxin-disulfide reductase (NADPH) activity. Predicted to be involved in cell redox homeostasis. Located in endomembrane system. Is expressed in adult head; adult heart; and organism. Orthologous to human SELENOT (selenoprotein T). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See SelT in Genome Data Viewer
    Location:
    25C1-25C1; 2-15 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (5010922..5012127)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (5010922..5012127)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Reticulon-like1 Neighboring gene uncharacterized protein Neighboring gene Transcription factor B5 Neighboring gene viking Neighboring gene Collagen type IV alpha 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Determinants of Endoplasmic Reticulum-to-Lipid Droplet Protein Targeting. Olarte MJ, et al. Dev Cell, 2020 Aug 24. PMID 32730754, Free PMC Article
    2. Genetic and metabolomic architecture of variation in diet restriction-mediated lifespan extension in Drosophila. Jin K, et al. PLoS Genet, 2020 Jul. PMID 32644988, Free PMC Article
    3. Protein correlation profiles identify lipid droplet proteins with high confidence. Krahmer N, et al. Mol Cell Proteomics, 2013 May. PMID 23319140, Free PMC Article
    4. Mapping organelle proteins and protein complexes in Drosophila melanogaster. Tan DJ, et al. J Proteome Res, 2009 Jun. PMID 19317464
    5. Proteome-wide association studies identify biochemical modules associated with a wing-size phenotype in Drosophila melanogaster. Okada H, et al. Nat Commun, 2016 Sep 1. PMID 27582081, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables thioredoxin-disulfide reductase (NADPH) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables thioredoxin-disulfide reductase (NADPH) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell redox homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in endomembrane system HDA PubMed 
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    selenoprotein T
    Names
    CG3887-PA
    CG3887-PB
    CG3887-PC
    SelT-PA
    SelT-PB
    SelT-PC
    SelT-like protein
    NP_001260069.1
    NP_001260070.1
    NP_608897.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      5010922..5012127
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273141.1 → NP_001260070.1  selenoprotein T, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260070.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VMV6
      UniProtKB/TrEMBL
      M9PCL4
      Conserved Domains (1) summary
      TIGR02174
      Location:44 → 182
      CXXU_selWTH; selT/selW/selH selenoprotein domain

    2. NM_135053.4 → NP_608897.1  selenoprotein T, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608897.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VMV6
      UniProtKB/TrEMBL
      M9PCL4
      Related
      FBpp0078639
      Conserved Domains (1) summary
      TIGR02174
      Location:44 → 182
      CXXU_selWTH; selT/selW/selH selenoprotein domain

    3. NM_001273140.1 → NP_001260069.1  selenoprotein T, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260069.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VMV6
      UniProtKB/TrEMBL
      M9PCL4
      Conserved Domains (1) summary
      TIGR02174
      Location:44 → 182
      CXXU_selWTH; selT/selW/selH selenoprotein domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PCL4 M9PCL4
    Q9VMV6.1 Q9VMV6

    Gene LinkOut

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