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    Aos1 Activator of SUMO 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41532, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Aos1provided by FlyBase
    Official Full Name
    Activator of SUMO 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0029512
    Locus tag
    Dmel_CG12276
    See related
    AllianceGenome:FB:FBgn0029512
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Aos; AOS1; CG12276; Dmaos1; DmAos1; Dmel\CG12276; DmSae1; DmSAE1; Sae1; SAE1
    Summary
    Enables ubiquitin activating enzyme binding activity and ubiquitin conjugating enzyme binding activity. Contributes to SUMO activating enzyme activity. Involved in several processes, including positive regulation of Toll signaling pathway; positive regulation of antimicrobial peptide production; and protein sumoylation. Located in nucleus. Is expressed in several structures, including Malpighian tubule primordium; antennal anlage; ganglia; germline cell; and head epidermis primordium. Used to study hematologic cancer. Orthologous to human SAE1 (SUMO1 activating enzyme subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Aos1 in Genome Data Viewer
    Location:
    87B10-87B10; 3-52 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (12432533..12433822, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (8258255..8259544, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene N-acetylneuraminic acid synthase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Proteasome alpha2 subunit Neighboring gene Spliceosome-ribosome linker protein Neighboring gene Desaturase 2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sumoylation is tumor-suppressive and confers proliferative quiescence to hematopoietic progenitors in Drosophila melanogaster larvae. Kalamarz ME, et al. Biol Open, 2012 Mar 15. PMID 23213407, Free PMC Article
    2. Expression of genes involved in sumoylation in the Drosophila germline. Hashiyama K, et al. Gene Expr Patterns, 2009 Jan. PMID 18755298
    3. Identification and characterization of a SUMO-1 conjugation system that modifies neuronal calcium/calmodulin-dependent protein kinase II in Drosophila melanogaster. Long X, et al. J Biol Chem, 2000 Dec 29. PMID 10995744
    4. Panoramix SUMOylation on chromatin connects the piRNA pathway to the cellular heterochromatin machinery. Andreev VI, et al. Nat Struct Mol Biol, 2022 Feb. PMID 35173350
    5. Drosophila CP190- and dCTCF-mediated enhancer blocking is augmented by SUMOylation. Jox T, et al. Epigenetics Chromatin, 2017. PMID 28680483, Free PMC Article

    See all (73) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    contributes_to SUMO activating enzyme activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin activating enzyme binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin conjugating enzyme binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin-like modifier activating enzyme activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of Toll signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of antimicrobial peptide production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein modification process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein sumoylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein sumoylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein sumoylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of SUMO activating enzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    activator of SUMO 1
    Names
    Aos1-PA
    CG12276-PA
    Smt3 activating enzyme 1
    ubiquitin activating enzyme
    ubiquitin activating enzyme 1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      12432533..12433822 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141941.3 → NP_650198.1  activator of SUMO 1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650198.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0ANV4, A0ANV7, A0ANV9, Q7KJV5, Q7KSM5, Q9U4A0, Q9VG70
      Related
      FBpp0082065
      Conserved Domains (2) summary
      cd01492
      Location:19 → 172
      Aos1_SUMO; Ubiquitin activating enzyme (E1) subunit Aos1. Aos1 is part of the heterodimeric activating enzyme (E1), specific for the SUMO family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...
      pfam00899
      Location:22 → 167
      ThiF; ThiF family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7KJV5 Q7KJV5
    Q7KSM5 Q7KSM5
    Q9VG70 Q9VG70

    Gene LinkOut

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