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    whd withered [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36109, updated on 17-Dec-2024

    Summary

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    Official Symbol
    whdprovided by FlyBase
    Official Full Name
    witheredprovided by FlyBase
    Primary source
    FLYBASE:FBgn0261862
    Locus tag
    Dmel_CG12891
    See related
    AllianceGenome:FB:FBgn0261862
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BEST:GH27794; CG12891; cpt1; Cpt1; CPT1; CPTI; dCPT1; Dmel\CG12891; gh27794
    Summary
    Predicted to enable carnitine O-palmitoyltransferase activity. Involved in response to metal ion; response to oxidative stress; and response to starvation. Located in endomembrane system. Is expressed in several structures, including adult head; adult heart; embryonic/larval midgut primordium; fat body; and ganglia. Human ortholog(s) of this gene implicated in carnitine palmitoyltransferase I deficiency; hereditary spastic paraplegia 73; and lipid metabolism disorder. Orthologous to several human genes including CPT1A (carnitine palmitoyltransferase 1A). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See whd in Genome Data Viewer
    Location:
    47A9-47A11; 2-62 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (10469473..10478567, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (6356978..6366072, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene G protein alpha subunit o Neighboring gene Cytochrome P450 49a1 Neighboring gene Chromatin assembly factor 1, p105 subunit Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45134 Neighboring gene translin Neighboring gene Peflin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The NF-κB Factor Relish maintains blood progenitor homeostasis in the developing Drosophila lymph gland. Ramesh P, et al. PLoS Genet, 2024 Sep. PMID 39250509, Free PMC Article
    2. Alternative exon usage in the single CPT1 gene of Drosophila generates functional diversity in the kinetic properties of the enzyme: differential expression of alternatively spliced variants in Drosophila tissues. Price NT, et al. J Biol Chem, 2010 Mar 12. PMID 20061394, Free PMC Article
    3. Sequencing and functional expression of the malonyl-CoA-sensitive carnitine palmitoyltransferase from Drosophila melanogaster. Jackson VN, et al. Biochem J, 1999 Aug 1. PMID 10417309, Free PMC Article
    4. Mitochondrial fusion and altered beta-oxidation drive muscle wasting in a Drosophila cachexia model. Dark C, et al. EMBO Rep, 2024 Apr. PMID 38429578, Free PMC Article
    5. 5-Aminolevulinic acid bypasses mitochondrial complex I deficiency and corrects physiological dysfunctions in Drosophila. Nozawa N, et al. Hum Mol Genet, 2023 Aug 7. PMID 37364055, Free PMC Article

    See all (91) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. alternative splicing that specifically affects a structurally crucial region of the protein is an important mechanism through which functional diversity of CPT1 kinetics is generated from the single gene that occurs in insects
      Title: Alternative exon usage in the single CPT1 gene of Drosophila generates functional diversity in the kinetic properties of the enzyme: differential expression of alternatively spliced variants in Drosophila tissues.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carnitine O-palmitoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables carnitine O-palmitoyltransferase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in carnitine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of fatty acid beta-oxidation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in fatty acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in endomembrane system HDA PubMed 
    is_active_in mitochondrial outer membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    withered
    Names
    CG12891-PA
    CG12891-PB
    CG12891-PC
    CG12891-PD
    carnitin-palmitoyl transferase-I
    carnitine PalmitoylTransferase 1
    carnitine-O-palmitoyltransferase
    mitochondrial carnitine palamitoyltransferase I
    mitochondrial carnitine palmitoyltransferase I
    whd-PA
    whd-PB
    whd-PC
    whd-PD
    NP_001163111.1
    NP_001163112.1
    NP_523685.2
    NP_724940.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      10469473..10478567 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078961.4 → NP_523685.2  withered, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523685.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JQH9
      Related
      FBpp0087399
      Conserved Domains (2) summary
      pfam00755
      Location:171 → 757
      Carn_acyltransf; Choline/Carnitine o-acyltransferase
      pfam16484
      Location:1 → 45
      CPT_N; Carnitine O-palmitoyltransferase N-terminus

    2. NM_001169640.2 → NP_001163111.1  withered, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163111.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V3K9
      Conserved Domains (2) summary
      pfam00755
      Location:171 → 759
      Carn_acyltransf; Choline/Carnitine o-acyltransferase
      pfam16484
      Location:1 → 45
      CPT_N; Carnitine O-palmitoyltransferase N-terminus

    3. NM_165777.3 → NP_724940.1  withered, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724940.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JQH9
      Related
      FBpp0087400
      Conserved Domains (2) summary
      pfam00755
      Location:171 → 757
      Carn_acyltransf; Choline/Carnitine o-acyltransferase
      pfam16484
      Location:1 → 45
      CPT_N; Carnitine O-palmitoyltransferase N-terminus

    4. NM_001169641.2 → NP_001163112.1  withered, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163112.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V3K9
      Conserved Domains (2) summary
      pfam00755
      Location:171 → 759
      Carn_acyltransf; Choline/Carnitine o-acyltransferase
      pfam16484
      Location:1 → 45
      CPT_N; Carnitine O-palmitoyltransferase N-terminus
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7JQH9 Q7JQH9
    Q9V3K9 Q9V3K9

    Gene LinkOut

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