Ufc1 Ubiquitin-fold modifier conjugating enzyme 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Ufc1provided by FlyBase
Official Full Name: Ubiquitin-fold modifier conjugating enzyme 1provided by FlyBase
Primary source: FLYBASE:FBgn0034061
Locus tag: Dmel_CG8386
See related: AllianceGenome:FB:FBgn0034061
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG8386; Dmel\CG8386; dUFC1
Summary: Predicted to enable UFM1 conjugating enzyme activity. Predicted to be involved in protein ufmylation; response to endoplasmic reticulum stress; and reticulophagy. Is expressed in several structures, including adult head; embryonic dorsal epidermis; embryonic/larval midgut primordium; gland; and gut section. Used to study neurodevelopmental disorder with spasticity and poor growth. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with spasticity and poor growth. Orthologous to human UFC1 (ubiquitin-fold modifier conjugating enzyme 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (16006893..16007667, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (11894398..11895172, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables UFM1 conjugating enzyme activity	IEA Inferred from Electronic Annotation more info
enables UFM1 conjugating enzyme activity	ISS Inferred from Sequence or Structural Similarity more info
enables UFM1 transferase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in protein ufmylation	IEA Inferred from Electronic Annotation more info
involved_in protein ufmylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to endoplasmic reticulum stress	IBA Inferred from Biological aspect of Ancestor more info
involved_in reticulophagy	IBA Inferred from Biological aspect of Ancestor more info

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