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    Prosbeta7 Proteasome beta7 subunit [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40639, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Prosbeta7provided by FlyBase
    Official Full Name
    Proteasome beta7 subunitprovided by FlyBase
    Primary source
    FLYBASE:FBgn0250746
    Locus tag
    Dmel_CG12000
    See related
    AllianceGenome:FB:FBgn0250746
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    12000; 154275_at; anon-WO0118547.326; beta-4; beta-7; Beta-7; beta7; CG12000; Dmel\CG12000; GC12000; Prosbeta4; Prot. beta4
    Summary
    Involved in centrosome cycle. Part of proteasome core complex. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in proteasome-associated autoinflammatory syndrome 3. Orthologous to human PSMB4 (proteasome 20S subunit beta 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Prosbeta7 in Genome Data Viewer
    Location:
    82F11-82F11; 3-47.5 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (5357012..5358364, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (1182734..1184086, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Ceramide kinase Neighboring gene long non-coding RNA:CR44103

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Proteasome Structure and Assembly. Budenholzer L, et al. J Mol Biol, 2017 Nov 10. PMID 28583440, Free PMC Article
    2. Caspase-dependent inactivation of proteasome function during programmed cell death in Drosophila and man. Adrain C, et al. J Biol Chem, 2004 Aug 27. PMID 15210720
    3. Identification of PSMB5 as a genetic modifier of fragile X-associated tremor/ataxia syndrome. Kong HE, et al. Proc Natl Acad Sci U S A, 2022 May 31. PMID 35617426, Free PMC Article
    4. The polyubiquitin gene Ubi-p63E is essential for male meiotic cell cycle progression and germ cell differentiation in Drosophila. Lu C, et al. Development, 2013 Sep. PMID 23884444, Free PMC Article
    5. 26S proteasome subunits are O-linked N-acetylglucosamine-modified in Drosophila melanogaster. Sümegi M, et al. Biochem Biophys Res Commun, 2003 Dec 26. PMID 14652013

    See all (66) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    NOT enables peptidase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in centrosome cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in proteolysis involved in protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of proteasome complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of proteasome core complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of proteasome core complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of proteasome core complex, beta-subunit complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of proteasome core complex, beta-subunit complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    proteasome beta7 subunit
    Names
    CG12000-PA
    CG12000-PB
    Prosbeta4
    Prosbeta7-PA
    Prosbeta7-PB
    beta-type 4 subunit
    beta7
    proteasome beta4 subunit

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      5357012..5358364 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141272.1 → NP_649529.1  proteasome beta7 subunit, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649529.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V2F4, Q9VNA5
      Related
      FBpp0078448, FBtr0078805
      Conserved Domains (2) summary
      COG0638
      Location:60 → 232
      PRE1; 20S proteasome, alpha and beta subunits [Posttranslational modification, protein turnover, chaperones]
      cd03760
      Location:60 → 252
      proteasome_beta_type_4; proteasome beta type-4 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that ...

    2. NM_169049.2 → NP_730922.1  proteasome beta7 subunit, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730922.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V2F4, Q9VNA5
      Related
      FBpp0078449
      Conserved Domains (2) summary
      COG0638
      Location:60 → 232
      PRE1; 20S proteasome, alpha and beta subunits [Posttranslational modification, protein turnover, chaperones]
      cd03760
      Location:60 → 252
      proteasome_beta_type_4; proteasome beta type-4 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VNA5.1 Q9VNA5

    Gene LinkOut

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