U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    promL prominin-like [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38372, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    promLprovided by FlyBase
    Official Full Name
    prominin-likeprovided by FlyBase
    Primary source
    FLYBASE:FBgn0026189
    Locus tag
    Dmel_CG7740
    See related
    AllianceGenome:FB:FBgn0026189
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    bs29e02.y1; CG7740; Dmel\CG7740; PromL
    Summary
    Involved in microvillus organization. Is active in apical plasma membrane. Is expressed in adult head; fat body; larval brain; and spermatozoon. Human ortholog(s) of this gene implicated in cone-rod dystrophy 12; retinal macular dystrophy 2; and retinitis pigmentosa 41. Orthologous to human PROM1 (prominin 1) and PROM2 (prominin 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See promL in Genome Data Viewer
    Location:
    63B1-63B3; 3-6 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (3114450..3127724, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (3114450..3127724, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene transfer RNA:Cysteine-GCA 1-4 Neighboring gene Chitinase 7 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene transfer RNA:Methionine-CAT 2-1 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45819 Neighboring gene ALG2, alpha-1,3/1,6-mannosyltransferase

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The prominin-like Gene Expressed in a Subset of Dopaminergic Neurons Regulates Locomotion in Drosophila. Ryu TH, et al. Mol Cells, 2022 Sep 30. PMID 35993164, Free PMC Article
    2. Apical and lateral cell protrusions interconnect epithelial cells in live Drosophila wing imaginal discs. Demontis F, et al. Dev Dyn, 2007 Dec. PMID 17854054
    3. Drosophila Prominin-like, a homolog of CD133, interacts with ND20 to maintain mitochondrial function. Wang X, et al. Cell Biosci, 2019. PMID 31890150, Free PMC Article
    4. A mosaic of independent innovations involving eyes shut are critical for the evolutionary transition from fused to open rhabdoms. Mahato S, et al. Dev Biol, 2018 Nov 15. PMID 30243673
    5. Microvilli-derived extracellular vesicles carry Hedgehog morphogenic signals for Drosophila wing imaginal disc development. Hurbain I, et al. Curr Biol, 2022 Jan 24. PMID 34890558

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in microvillus organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    prominin-like
    Names
    CG7740-PA
    CG7740-PB
    CG7740-PC
    CG7740-PD
    CG7740-PE
    CG7740-PG
    CG7740-PH
    Prominin-like
    promL-PA
    promL-PB
    promL-PC
    promL-PD
    promL-PE
    promL-PG
    promL-PH
    prominin-like protein

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      3114450..3127724 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001259658.3 → NP_001246587.1  prominin-like, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246587.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PDX6
      Conserved Domains (1) summary
      pfam05478
      Location:76 → 881
      Prominin; Prominin

    2. NM_167987.4 → NP_728810.1  prominin-like, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728810.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V1D5, A8WHI2, P82295, Q95RK1, Q9VZV0
      UniProtKB/TrEMBL
      M9PH44
      Related
      FBpp0072980
      Conserved Domains (1) summary
      pfam05478
      Location:76 → 881
      Prominin; Prominin

    3. NM_139513.3 → NP_647770.1  prominin-like, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647770.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V1D5, A8WHI2, P82295, Q95RK1, Q9VZV0
      UniProtKB/TrEMBL
      M9PH44
      Related
      FBpp0072981
      Conserved Domains (1) summary
      pfam05478
      Location:76 → 881
      Prominin; Prominin

    4. NM_001274424.1 → NP_001261353.1  prominin-like, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261353.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PDX6
      Conserved Domains (1) summary
      pfam05478
      Location:76 → 881
      Prominin; Prominin

    5. NM_167986.1 → NP_728809.1  prominin-like, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728809.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V1D5, A8WHI2, P82295, Q95RK1, Q9VZV0
      UniProtKB/TrEMBL
      M9PH44
      Related
      FBpp0072982, FBtr0073120
      Conserved Domains (1) summary
      pfam05478
      Location:76 → 881
      Prominin; Prominin

    6. NM_001274422.1 → NP_001261351.1  prominin-like, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261351.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V1D5, A8WHI2, P82295, Q95RK1, Q9VZV0
      UniProtKB/TrEMBL
      M9PH44
      Conserved Domains (1) summary
      pfam05478
      Location:76 → 881
      Prominin; Prominin

    7. NM_001382193.1 → NP_001368963.1  prominin-like, isoform H [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      H5V897, M9PBK6
      Conserved Domains (1) summary
      pfam05478
      Location:76 → 881
      Prominin
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PBK6 M9PBK6
    M9PDX6 M9PDX6
    M9PH44 M9PH44
    P82295.1 P82295

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools