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    Ogg1 8-oxoguanine DNA glycosylase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31806, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ogg1provided by FlyBase
    Official Full Name
    8-oxoguanine DNA glycosylaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0027864
    Locus tag
    Dmel_CG1795
    See related
    AllianceGenome:FB:FBgn0027864
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    1795; BcDNA:LD19945; CG1795; Dmel\CG1795; dOgg1; dOGG1; OGG1
    Summary
    Enables DNA N-glycosylase activity and class I DNA-(apurinic or apyrimidinic site) endonuclease activity. Involved in base-excision repair and cellular response to oxidative stress. Predicted to be located in mitochondrion. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in several diseases, including Graves' disease; artery disease (multiple); carcinoma (multiple); eye disease (multiple); and reproductive organ cancer (multiple). Orthologous to human OGG1 (8-oxoguanine DNA glycosylase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ogg1 in Genome Data Viewer
    Location:
    8A2-8A2; 1-24 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (8690327..8691811)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (8584360..8585844)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene rubicon Neighboring gene Carbonic anhydrase 3 Neighboring gene Palmitoyl-protein thioesterase 1 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44507 Neighboring gene long non-coding RNA:CR44508

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila Ogg1 is required to suppress 8-oxo-guanine accumulation following oxidative stress. Yasukawa T, et al. Genes Genet Syst, 2015. PMID 26119662
    2. Repair of oxidative DNA damage in Drosophila melanogaster: identification and characterization of dOgg1, a second DNA glycosylase activity for 8-hydroxyguanine and formamidopyrimidines. Dherin C, et al. Nucleic Acids Res, 2000 Dec 1. PMID 11095666, Free PMC Article
    3. Oxidative stress is not a major contributor to somatic mitochondrial DNA mutations. Itsara LS, et al. PLoS Genet, 2014 Feb. PMID 24516391, Free PMC Article
    4. Effects of ectopic expression of Drosophila DNA glycosylases dOgg1 and RpS3 in mitochondria. Radyuk SN, et al. Free Radic Biol Med, 2006 Sep 1. PMID 16895796, Free PMC Article
    5. Age- and oxidative stress-induced DNA damage in Drosophila intestinal stem cells as marked by Gamma-H2AX. Park JS, et al. Exp Gerontol, 2012 May. PMID 22387531

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. dOgg1 and RpS3 in mitochondria increase cell survival after exposure to the nitric oxide donor SNAP
      Title: Effects of ectopic expression of Drosophila DNA glycosylases dOgg1 and RpS3 in mitochondria.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA N-glycosylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables class I DNA-(apurinic or apyrimidinic site) endonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables damaged DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidized purine nucleobase lesion DNA N-glycosylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in base-excision repair IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in base-excision repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in base-excision repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in base-excision repair, AP site formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nucleotide-excision repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    8-oxoguanine DNA glycosylase
    Names
    CG1795-PA
    Ogg1-PA
    NP_572499.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      8690327..8691811
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132271.5 → NP_572499.2  8-oxoguanine DNA glycosylase [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572499.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9V3I8
      UniProtKB/TrEMBL
      C4IXZ6, Q6NL83
      Related
      FBpp0071168
      Conserved Domains (3) summary
      TIGR00588
      Location:33 → 324
      ogg; 8-oxoguanine DNA-glycosylase (ogg)
      cd00056
      Location:137 → 318
      ENDO3c; endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases
      pfam07934
      Location:26 → 140
      OGG_N; 8-oxoguanine DNA glycosylase, N-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9V3I8.2 Q9V3I8

    Gene LinkOut

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