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    frj farjavit [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33900, updated on 9-Dec-2024

    Summary

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    Official Symbol
    frjprovided by FlyBase
    Official Full Name
    farjavitprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031815
    Locus tag
    Dmel_CG9526
    See related
    AllianceGenome:FB:FBgn0031815
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9526; CT26954; Dmel\CG9526; Frj; MBOAT
    Summary
    Enables lysophospholipid acyltransferase activity. Involved in lipid modification. Located in membrane. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; germline cell; head epidermis primordium; and mesoderm. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 57. Orthologous to human MBOAT7 (membrane bound O-acyltransferase domain containing 7). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See frj in Genome Data Viewer
    Location:
    26D5-26D5; 2-20 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6456052..6459008)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6456052..6459008)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Acyl-CoA oxidase 3 Neighboring gene real-time Neighboring gene Ring finger and CHY zinc finger domain containing 1 Neighboring gene HemK methyltransferase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila lysophospholipid acyltransferases are specifically required for germ cell development. Steinhauer J, et al. Mol Biol Cell, 2009 Dec. PMID 19864461, Free PMC Article
    2. Drosophila model for studying the link between lipid metabolism and development. Thanh MT, et al. Front Biosci (Landmark Ed), 2020 Jan 1. PMID 31585882
    3. Exploring developmental and physiological functions of fatty acid and lipid variants through worm and fly genetics. Zhu H, et al. Annu Rev Genet, 2014. PMID 25195508
    4. Protein correlation profiles identify lipid droplet proteins with high confidence. Krahmer N, et al. Mol Cell Proteomics, 2013 May. PMID 23319140, Free PMC Article
    5. Selection for cold resistance alters gene transcript levels in Drosophila melanogaster. Telonis-Scott M, et al. J Insect Physiol, 2009 Jun. PMID 19232407

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables lysophospholipid acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lysophospholipid acyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in lipid modification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lipid modification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phosphatidylinositol biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitochondria-associated endoplasmic reticulum membrane contact site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    farjavit
    Names
    CG9526-PA
    CG9526-PB
    frj-PA
    frj-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      6456052..6459008
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_205915.3 → NP_995637.1  farjavit, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995637.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VMD5
      Conserved Domains (1) summary
      pfam03062
      Location:93 → 427
      MBOAT; membrane-bound O-acyltransferase family

    2. NM_135185.4 → NP_609029.1  farjavit, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609029.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VMD5
      Related
      FBpp0078888
      Conserved Domains (1) summary
      pfam03062
      Location:93 → 427
      MBOAT; membrane-bound O-acyltransferase family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VMD5.1 Q9VMD5

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