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    NTPase NTPase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33495, updated on 9-Dec-2024

    Summary

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    Official Symbol
    NTPaseprovided by FlyBase
    Official Full Name
    NTPaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0024947
    Locus tag
    Dmel_CG3059
    See related
    AllianceGenome:FB:FBgn0024947
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3059; Dmel\CG3059; dmNTPase; NTPDase6
    Summary
    Enables GDP phosphatase activity; IDP phosphatase activity; and UDP phosphatase activity. Predicted to be involved in nucleoside diphosphate catabolic process. Located in cytoplasm. Is expressed in several structures, including adult head; adult heart; gland; and salivary gland body primordium. Orthologous to human ENTPD5 (ectonucleoside triphosphate diphosphohydrolase 5 (inactive)) and ENTPD6 (ectonucleoside triphosphate diphosphohydrolase 6). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See NTPase in Genome Data Viewer
    Location:
    23C1-23C1; 2-8 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (2880704..2885850, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (2880704..2885850, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Rab geranylgeranyltransferase subunit beta Neighboring gene Peroxiredoxin 6a Neighboring gene Sabbat Neighboring gene lilliputian Neighboring gene RNA-binding protein 9 Neighboring gene Thymidylate synthase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The single NTPase gene of Drosophila melanogaster encodes an intracellular nucleoside triphosphate diphosphohydrolase 6 (NTPDase6). Knowles AF. Arch Biochem Biophys, 2009 Apr 1. PMID 19467631
    2. The CD39-like gene family: identification of three new human members (CD39L2, CD39L3, and CD39L4), their murine homologues, and a member of the gene family from Drosophila melanogaster. Chadwick BP, et al. Genomics, 1998 Jun 15. PMID 9676430
    3. Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity. Turcot V, et al. Nat Genet, 2018 Jan. PMID 29273807, Free PMC Article
    4. Lilliputian: an AF4/FMR2-related protein that controls cell identity and cell growth. Wittwer F, et al. Development, 2001 Mar. PMID 11171403
    5. Glia instruct axon regeneration via a ternary modulation of neuronal calcium channels in Drosophila. Trombley S, et al. Nat Commun, 2023 Oct 14. PMID 37838791, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GDP phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables IDP phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables UDP phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    NTPase
    Names
    CD39-like NTPase
    CG3059-PA
    CG3059-PC
    CG3059-PD
    CG3059-PE
    CG3059-PF
    NTPase-PA
    NTPase-PC
    NTPase-PD
    NTPase-PE
    NTPase-PF
    NP_001259972.1
    NP_477370.1
    NP_722860.1
    NP_722861.1
    NP_722862.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      2880704..2885850 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_164515.3 → NP_722862.1  NTPase, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_722862.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IPZ6
      Related
      FBpp0077364
      Conserved Domains (1) summary
      cl17037
      Location:2 → 269
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    2. NM_164513.4 → NP_722860.1  NTPase, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_722860.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D5AEL4, Q9VQI8
      Related
      FBpp0304732
      Conserved Domains (1) summary
      cl17037
      Location:80 → 462
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    3. NM_001273043.1 → NP_001259972.1  NTPase, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259972.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D5AEL4, M9PBV2
      Conserved Domains (1) summary
      cl17037
      Location:140 → 522
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    4. NM_164514.3 → NP_722861.1  NTPase, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_722861.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IPZ6
      Related
      FBpp0077366
      Conserved Domains (1) summary
      cl17037
      Location:2 → 269
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    5. NM_058022.5 → NP_477370.1  NTPase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477370.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D5AEL4, O76268
      Related
      FBpp0077367
      Conserved Domains (1) summary
      cl17037
      Location:77 → 459
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PBV2 M9PBV2
    O76268 O76268
    Q8IPZ6 Q8IPZ6
    Q9VQI8 Q9VQI8

    Gene LinkOut

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