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    kappaB-Ras kappaB-Ras [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35667, updated on 9-Dec-2024

    Summary

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    Official Symbol
    kappaB-Rasprovided by FlyBase
    Official Full Name
    kappaB-Rasprovided by FlyBase
    Primary source
    FLYBASE:FBgn0040513
    Locus tag
    Dmel_CG1669
    See related
    AllianceGenome:FB:FBgn0040513
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    B7YZS7; BcDNA:RH38596; CG1669; dkappaB-Ras; Dmel\CG1669; Q9V4L4-1
    Summary
    Enables IkappaB kinase complex binding activity. Predicted to be involved in Ral protein signal transduction. Orthologous to human NKIRAS1 (NFKB inhibitor interacting Ras like 1) and NKIRAS2 (NFKB inhibitor interacting Ras like 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See kappaB-Ras in Genome Data Viewer
    Location:
    43C1-43C1; 2-56 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7443824..7445792, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3331329..3333297, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene sine oculis Neighboring gene long non-coding RNA:CR44204 Neighboring gene uncharacterized protein Neighboring gene secretory Phospholipase A2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Fatty acid 2-hydroxylase Neighboring gene long non-coding RNA:CR45320

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Disruption of INOS, a Gene Encoding myo-Inositol Phosphate Synthase, Causes Male Sterility in Drosophila melanogaster. Jackson NAM, et al. G3 (Bethesda), 2018 Aug 30. PMID 29991509, Free PMC Article
    2. A subclass of Ras proteins that regulate the degradation of IkappaB. Fenwick C, et al. Science, 2000 Feb 4. PMID 10657303
    3. Insights from natural host-parasite interactions: the Drosophila model. Keebaugh ES, et al. Dev Comp Immunol, 2014 Jan. PMID 23764256, Free PMC Article
    4. Evolutionary expansion of the Ras switch regulatory module in eukaryotes. Díez D, et al. Nucleic Acids Res, 2011 Jul. PMID 21447561, Free PMC Article
    5. Human RAS superfamily proteins and related GTPases. Colicelli J. Sci STKE, 2004 Sep 7. PMID 15367757, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTP binding ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    enables GTPase activating protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT enables GTPase activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    enables IkappaB kinase complex binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Ral protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of canonical NF-kappaB signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    kappaB-Ras
    Names
    CG1669-PA
    CG1669-PB
    CG1669-PC
    kappaB-Ras-PA
    kappaB-Ras-PB
    kappaB-Ras-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      7443824..7445792 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001144141.3 → NP_001137613.1  kappaB-Ras, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137613.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q86P69, Q9NH91, Q9V4L4
      UniProtKB/TrEMBL
      B7YZS7
      Conserved Domains (2) summary
      cd00882
      Location:13 → 174
      Ras_like_GTPase; Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases)
      pfam00071
      Location:11 → 173
      Ras; Ras family

    2. NM_136434.5 → NP_610278.1  kappaB-Ras, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610278.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q86P69, Q9NH91, Q9V4L4
      UniProtKB/TrEMBL
      B7YZS7
      Related
      FBpp0088074
      Conserved Domains (2) summary
      cd00882
      Location:13 → 174
      Ras_like_GTPase; Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases)
      pfam00071
      Location:11 → 173
      Ras; Ras family

    3. NM_001273841.1 → NP_001260770.1  kappaB-Ras, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260770.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q86P69, Q9NH91, Q9V4L4
      UniProtKB/TrEMBL
      B7YZS7
      Conserved Domains (2) summary
      cd00882
      Location:13 → 174
      Ras_like_GTPase; Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases)
      pfam00071
      Location:11 → 173
      Ras; Ras family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B7YZS7 B7YZS7
    Q9V4L4.1 Q9V4L4

    Gene LinkOut

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