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    Eaat2 Excitatory amino acid transporter 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33247, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Eaat2provided by FlyBase
    Official Full Name
    Excitatory amino acid transporter 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0026438
    Locus tag
    Dmel_CG3159
    See related
    AllianceGenome:FB:FBgn0026438
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3159; dEaat2; dEAAT2; Dmel\CG3159; EAAT; Eaat 2; EAAT2
    Summary
    Enables L-aspartate transmembrane transporter activity and taurine:sodium symporter activity. Involved in taurine transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including ganglia; glial cell; olfactory system neurons; sense organ; and synaptic neuropil domain. Used to study developmental and epileptic encephalopathy 41. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 41. Orthologous to human SLC1A2 (solute carrier family 1 member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Eaat2 in Genome Data Viewer
    Location:
    21E2-21E2; 2-1.5 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (737212..744395, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (737212..744395, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR46260 Neighboring gene Heat shock protein 60B Neighboring gene metabotropic GABA-B receptor subtype 3 Neighboring gene long non-coding RNA:CR44614

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Taurine Transporter dEAAT2 is Required for Auditory Transduction in Drosophila. Sun Y, et al. Neurosci Bull, 2018 Dec. PMID 30043098, Free PMC Article
    2. Identification and structural characterization of two genes encoding glutamate transporter homologues differently expressed in the nervous system of Drosophila melanogaster. Besson MT, et al. FEBS Lett, 1999 Jan 25. PMID 9989583
    3. High affinity transport of taurine by the Drosophila aspartate transporter dEAAT2. Besson MT, et al. J Biol Chem, 2005 Feb 25. PMID 15611131
    4. The Taurine Transporter Eaat2 Functions in Ensheathing Glia to Modulate Sleep and Metabolic Rate. Stahl BA, et al. Curr Biol, 2018 Nov 19. PMID 30416062
    5. Selective high-affinity transport of aspartate by a Drosophila homologue of the excitatory amino-acid transporters. Besson MT, et al. Curr Biol, 2000 Feb 24. PMID 10704415

    See all (62) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Dtudy identified Excitatory amino acid transporter 2 (Eaat2) and found that its loss from glia, but not neurons, increases sleep. Authors show that Eaat2 is expressed in ensheathing glia, where Eaat2 functions during adulthood to regulate sleep.
      Title: The Taurine Transporter Eaat2 Functions in Ensheathing Glia to Modulate Sleep and Metabolic Rate.
    2. These findings indicate a critical role for Drosophila dEAAT2 in sound transduction by chordotonal neurons
      Title: Taurine Transporter dEAAT2 is Required for Auditory Transduction in Drosophila.
    3. Data suggest that EAAT2 functions as a taurine transporter in vivo and is physiologically required for the sensory perception of specific environmental molecules.
      Title: Involvement of the Drosophila taurine/aspartate transporter dEAAT2 in selective olfactory and gustatory perceptions.
    4. Terminal glial differentiation involves regulated expression of the excitatory amino acid transporters in the Drosophila embryonic CNS.
      Title: Terminal glial differentiation involves regulated expression of the excitatory amino acid transporters in the Drosophila embryonic CNS.
    5. Taurine and aspartate are transported with similar K(m) and relative efficacy and behave as mutually competitive inhibitors; dEAAT2 is actually an aspartate/taurine transporter
      Title: High affinity transport of taurine by the Drosophila aspartate transporter dEAAT2.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables L-aspartate transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables L-glutamate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutamate:sodium symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutamate:sodium symporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables neutral L-amino acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables taurine:sodium symporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in L-glutamate transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in taurine transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in taurine transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    excitatory amino acid transporter 2
    Names
    CG3159-PA
    CG3159-PC
    CG3159-PD
    Eaat2-PA
    Eaat2-PC
    Eaat2-PD
    sodium-dependent excitatory amino acid transporter 2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      737212..744395 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058079.3 → NP_477427.1  excitatory amino acid transporter 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477427.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U9K1, Q9VPS6
      Related
      FBpp0077707
      Conserved Domains (1) summary
      pfam00375
      Location:35 → 480
      SDF; Sodium:dicarboxylate symporter family

    2. NM_001169374.2 → NP_001162845.1  excitatory amino acid transporter 2, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162845.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U9K1, Q9VPS6
      Conserved Domains (1) summary
      pfam00375
      Location:35 → 480
      SDF; Sodium:dicarboxylate symporter family

    3. NM_001169373.2 → NP_001162844.1  excitatory amino acid transporter 2, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162844.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JHQ6, Q9U9K1
      Conserved Domains (1) summary
      pfam00375
      Location:51 → 496
      SDF; Sodium:dicarboxylate symporter family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E1JHQ6 E1JHQ6
    Q8T0S9 Q8T0S9
    Q9U9K1 Q9U9K1
    Q9VPS6 Q9VPS6

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