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    CtsB Cathepsin B [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32341, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CtsBprovided by FlyBase
    Official Full Name
    Cathepsin Bprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030521
    Locus tag
    Dmel_CG10992
    See related
    AllianceGenome:FB:FBgn0030521
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:ParkEST132; CathB; CB; CG-10992; CG10992; CTSB; Ctsb1; CtsB1; CTSB1; Dmel\CG10992
    Summary
    Enables cysteine-type endopeptidase activity. Involved in proteolysis. Located in perivitelline space. Is expressed in several structures, including adult brain cell body rind; adult head; adult heart; apoptotic amnioserosa; and ganglia. Human ortholog(s) of this gene implicated in diabetes mellitus. Orthologous to human CTSB (cathepsin B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CtsB in Genome Data Viewer
    Location:
    12C4-12C4; 1-46 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (13779847..13782170, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (13673880..13676203, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Yolk protein 3 Neighboring gene retinal degeneration B Neighboring gene amaretto Neighboring gene inactivation no afterpotential E Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Residue-specific annotation of disorder-to-order transition and cathepsin inhibition of a propeptide-like crammer from D. melanogaster. Tseng TS, et al. PLoS One, 2013. PMID 23349821, Free PMC Article
    2. A molten globule-to-ordered structure transition of Drosophila melanogaster crammer is required for its ability to inhibit cathepsin. Tseng TS, et al. Biochem J, 2012 Mar 15. PMID 22150223, Free PMC Article
    3. Drosophila melanogaster cellular repressor of E1A-stimulated genes is a lysosomal protein essential for fly development. Kowalewski-Nimmerfall E, et al. Biochim Biophys Acta, 2014 Dec. PMID 25173815, Free PMC Article
    4. Cp1/cathepsin L is required for autolysosomal clearance in Drosophila. Xu T, et al. Autophagy, 2021 Oct. PMID 33112206, Free PMC Article
    5. Drosophila GGA model: an ultimate gateway to GGA analysis. Eissenberg JC, et al. Traffic, 2011 Dec. PMID 21923734, Free PMC Article

    See all (60) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cysteine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cysteine-type peptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables peptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis involved in protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in perivitelline space HDA PubMed 

    General protein information

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    Preferred Names
    cathepsin B
    Names
    CG10992-PA
    CG10992-PC
    CtsB-PA
    CtsB-PC
    cathepsin B1
    NP_001259536.2
    NP_572920.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      13779847..13782170 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272607.2 → NP_001259536.2  cathepsin B, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259536.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PH35, Q9VY87
      Conserved Domains (2) summary
      cd02620
      Location:88 → 336
      Peptidase_C1A_CathepsinB; Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an ...
      pfam08127
      Location:24 → 64
      Propeptide_C1; Peptidase family C1 propeptide

    2. NM_132692.3 → NP_572920.1  cathepsin B, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572920.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PH35, Q9VY87
      Related
      FBpp0073669
      Conserved Domains (2) summary
      cd02620
      Location:88 → 336
      Peptidase_C1A_CathepsinB; Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an ...
      pfam08127
      Location:24 → 64
      Propeptide_C1; Peptidase family C1 propeptide
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VY87 Q9VY87

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