U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    CG2246 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43637, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    CG2246provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039790
    Locus tag
    Dmel_CG2246
    See related
    AllianceGenome:FB:FBgn0039790
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG2246
    Summary
    Predicted to enable enzyme regulator activity. Predicted to be involved in 5-phosphoribose 1-diphosphate biosynthetic process and purine nucleotide biosynthetic process. Predicted to be active in cytoplasm. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; gut section; mesoderm; and visceral mesoderm derivative. Orthologous to several human genes including PRPSAP2 (phosphoribosyl pyrophosphate synthetase associated protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See CG2246 in Genome Data Viewer
    Location:
    99F10-100A1; 3-100 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (30592971..30601489, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (26418693..26427211, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Regulatory particle triple-A ATPase 6-related Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene prolyl-4-hydroxylase-alpha NE3

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. PRPS-Associated Disorders and the Drosophila Model of Arts Syndrome. Delos Santos K, et al. Int J Mol Sci, 2020 Jul 8. PMID 32650483, Free PMC Article
    2. A computational and experimental approach toward a priori identification of alternatively spliced exons. Philipps DL, et al. RNA, 2004 Dec. PMID 15525709, Free PMC Article
    3. Proteins rather than mRNAs regulate nucleation and persistence of Oskar germ granules in Drosophila. Curnutte HA, et al. Cell Rep, 2023 Jul 25. PMID 37384531, Free PMC Article
    4. Genome-wide phenotypic RNAi screen in the Drosophila wing: global parameters. López-Varea A, et al. G3 (Bethesda), 2021 Dec 8. PMID 34599819, Free PMC Article
    5. Sex-Specific Transcript Diversity in the Fly Head Is Established during Pupal Stages and Adulthood and Is Largely Independent of the Mating Process and the Germline. Mohr C, et al. Sex Dev, 2017. PMID 28273663

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables enzyme regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in 5-phosphoribose 1-diphosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in purine nucleotide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    uncharacterized protein
    Names
    CG2246-PA
    CG2246-PB
    CG2246-PC
    CG2246-PD
    CG2246-PE
    CG2246-PF
    CG2246-PG
    CG2246-PH
    CG2246-PI
    CG2246-PJ
    CG2246-PK
    CG2246-PL
    CG2246-PM
    CG2246-PN
    CG2246-PO
    CG2246-PP
    NP_001163778.1
    NP_001189321.1
    NP_001189322.1
    NP_001189323.1
    NP_001189324.1
    NP_001189325.1
    NP_001189326.1
    NP_001263115.1
    NP_001263116.1
    NP_001263117.1
    NP_651813.2
    NP_733386.1
    NP_733387.1
    NP_733388.1
    NP_733389.2
    NP_733390.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      30592971..30601489 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001202395.2 → NP_001189324.1  uncharacterized protein Dmel_CG2246, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189324.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q961V3
      Conserved Domains (2) summary
      pfam13793
      Location:9 → 124
      Pribosyltran_N; N-terminal domain of ribose phosphate pyrophosphokinase
      pfam14572
      Location:165 → 361
      Pribosyl_synth; Phosphoribosyl synthetase-associated domain

    2. NM_170511.2 → NP_733390.1  uncharacterized protein Dmel_CG2246, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733390.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KRU0
      Related
      FBpp0085036
      Conserved Domains (2) summary
      pfam13793
      Location:9 → 124
      Pribosyltran_N; N-terminal domain of ribose phosphate pyrophosphokinase
      pfam14572
      Location:165 → 380
      Pribosyl_synth; Phosphoribosyl synthetase-associated domain

    3. NM_170507.2 → NP_733386.1  uncharacterized protein Dmel_CG2246, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733386.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IMI0
      Related
      FBpp0085037
      Conserved Domains (2) summary
      pfam13793
      Location:29 → 144
      Pribosyltran_N; N-terminal domain of ribose phosphate pyrophosphokinase
      pfam14572
      Location:185 → 381
      Pribosyl_synth; Phosphoribosyl synthetase-associated domain

    4. NM_001202392.2 → NP_001189321.1  uncharacterized protein Dmel_CG2246, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189321.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VA53
      Conserved Domains (2) summary
      pfam13793
      Location:29 → 144
      Pribosyltran_N; N-terminal domain of ribose phosphate pyrophosphokinase
      pfam14572
      Location:185 → 400
      Pribosyl_synth; Phosphoribosyl synthetase-associated domain

    5. NM_170510.2 → NP_733389.2  uncharacterized protein Dmel_CG2246, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733389.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VA53
      Related
      FBpp0085035
      Conserved Domains (2) summary
      pfam13793
      Location:29 → 144
      Pribosyltran_N; N-terminal domain of ribose phosphate pyrophosphokinase
      pfam14572
      Location:185 → 400
      Pribosyl_synth; Phosphoribosyl synthetase-associated domain

    6. NM_001202396.2 → NP_001189325.1  uncharacterized protein Dmel_CG2246, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189325.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q961V3
      Conserved Domains (2) summary
      pfam13793
      Location:9 → 124
      Pribosyltran_N; N-terminal domain of ribose phosphate pyrophosphokinase
      pfam14572
      Location:165 → 361
      Pribosyl_synth; Phosphoribosyl synthetase-associated domain

    7. NM_001202397.2 → NP_001189326.1  uncharacterized protein Dmel_CG2246, isoform M [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189326.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q961V3
      Conserved Domains (2) summary
      pfam13793
      Location:9 → 124
      Pribosyltran_N; N-terminal domain of ribose phosphate pyrophosphokinase
      pfam14572
      Location:165 → 361
      Pribosyl_synth; Phosphoribosyl synthetase-associated domain

    8. NM_001276188.1 → NP_001263117.1  uncharacterized protein Dmel_CG2246, isoform P [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001263117.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KHW7
      Conserved Domains (3) summary
      COG0462
      Location:5 → 350
      PrsA; Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism, Amino acid transport and metabolism]
      pfam13793
      Location:9 → 124
      Pribosyltran_N; N-terminal domain of ribose phosphate pyrophosphokinase
      pfam14572
      Location:165 → 350
      Pribosyl_synth; Phosphoribosyl synthetase-associated domain

    9. NM_170508.2 → NP_733387.1  uncharacterized protein Dmel_CG2246, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733387.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q961V3
      Related
      FBpp0085038
      Conserved Domains (2) summary
      pfam13793
      Location:9 → 124
      Pribosyltran_N; N-terminal domain of ribose phosphate pyrophosphokinase
      pfam14572
      Location:165 → 361
      Pribosyl_synth; Phosphoribosyl synthetase-associated domain

    10. NM_143556.4 → NP_651813.2  uncharacterized protein Dmel_CG2246, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651813.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KRU0
      Related
      FBpp0085040
      Conserved Domains (2) summary
      pfam13793
      Location:9 → 124
      Pribosyltran_N; N-terminal domain of ribose phosphate pyrophosphokinase
      pfam14572
      Location:165 → 380
      Pribosyl_synth; Phosphoribosyl synthetase-associated domain

    11. NM_170509.2 → NP_733388.1  uncharacterized protein Dmel_CG2246, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733388.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q961V3
      Related
      FBpp0085039
      Conserved Domains (2) summary
      pfam13793
      Location:9 → 124
      Pribosyltran_N; N-terminal domain of ribose phosphate pyrophosphokinase
      pfam14572
      Location:165 → 361
      Pribosyl_synth; Phosphoribosyl synthetase-associated domain

    12. NM_001202394.2 → NP_001189323.1  uncharacterized protein Dmel_CG2246, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189323.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4JD23
      Conserved Domains (2) summary
      pfam13793
      Location:27 → 142
      Pribosyltran_N; N-terminal domain of ribose phosphate pyrophosphokinase
      pfam14572
      Location:183 → 379
      Pribosyl_synth; Phosphoribosyl synthetase-associated domain

    13. NM_001202393.2 → NP_001189322.1  uncharacterized protein Dmel_CG2246, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189322.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4JDE3
      Conserved Domains (2) summary
      pfam13793
      Location:27 → 142
      Pribosyltran_N; N-terminal domain of ribose phosphate pyrophosphokinase
      pfam14572
      Location:183 → 398
      Pribosyl_synth; Phosphoribosyl synthetase-associated domain

    14. NM_001276186.1 → NP_001263115.1  uncharacterized protein Dmel_CG2246, isoform N [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001263115.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KHJ3
      Conserved Domains (2) summary
      pfam13793
      Location:29 → 144
      Pribosyltran_N; N-terminal domain of ribose phosphate pyrophosphokinase
      pfam14572
      Location:185 → 370
      Pribosyl_synth; Phosphoribosyl synthetase-associated domain

    15. NM_001276187.1 → NP_001263116.1  uncharacterized protein Dmel_CG2246, isoform O [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001263116.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KHF5
      Conserved Domains (2) summary
      pfam13793
      Location:29 → 144
      Pribosyltran_N; N-terminal domain of ribose phosphate pyrophosphokinase
      pfam14572
      Location:185 → 371
      Pribosyl_synth; Phosphoribosyl synthetase-associated domain

    16. NM_001170307.1 → NP_001163778.1  uncharacterized protein Dmel_CG2246, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163778.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IMI0
      Conserved Domains (2) summary
      pfam13793
      Location:29 → 144
      Pribosyltran_N; N-terminal domain of ribose phosphate pyrophosphokinase
      pfam14572
      Location:185 → 381
      Pribosyl_synth; Phosphoribosyl synthetase-associated domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4JD23 A0A0B4JD23
    A0A0B4JDE3 A0A0B4JDE3
    A0A0B4KHF5 A0A0B4KHF5
    A0A0B4KHJ3 A0A0B4KHJ3
    A0A0B4KHW7 A0A0B4KHW7
    Q7KRU0 Q7KRU0
    Q8IMI0 Q8IMI0
    Q961V3 Q961V3
    Q9VA53 Q9VA53

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools