Epac Exchange protein directly activated by cAMP [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Epacprovided by FlyBase
Official Full Name: Exchange protein directly activated by cAMPprovided by FlyBase
Primary source: FLYBASE:FBgn0085421
Locus tag: Dmel_CG34392
See related: AllianceGenome:FB:FBgn0085421
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG15235; CG3427; CG34392; D-Epac; D-EPAC; Dmel\CG34392; Dm_2R:10367; epac
Old locus tag: CG15235; CG3427; Dmel_CG15235; Dmel_CG3427
Summary: Predicted to enable guanyl-nucleotide exchange factor activity. Involved in regulation of Rap protein signal transduction. Predicted to be active in plasma membrane. Is expressed in adult head; midline glial cell; and midline primordium. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to several human genes including RAPGEF4 (Rap guanine nucleotide exchange factor 4). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 42C8-42D1; 2-55 cM

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (6759715..6798941, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (2647220..2686446, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This study revealed epac mutation impaired the aversive odor learning in Drosophila.
Title: Null EPAC mutants reveal a sequential order of versatile cAMP effects during Drosophila aversive odor learning.
The role of Epac within blood vessels: regulation of vascular tone; endothelial barrier function and inflammation. [Review]
Title: cAMP signalling in the vasculature: the role of Epac (exchange protein directly activated by cAMP).
EPAC is important in stimulated fluid secretion in Malpighian tubule stelate and principal cells.
Title: Separate roles of PKA and EPAC in renal function unraveled by the optogenetic control of cAMP levels in vivo.
Epac expression is modulated by juvenile hormone dose-dependently.
Title: Juvenile hormone regulation of Drosophila Epac--a guanine nucleotide exchange factor.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables guanyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Ras protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of Rap protein signal transduction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in small GTPase-mediated signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: exchange protein directly activated by cAMP

Names: CG34392-PD; CG34392-PE; CG34392-PF; CG34392-PH; Epac-PD; Epac-PE; Epac-PF; Epac-PH; epac guanine nucleotide exchange factor; exchange protein directly activated by cAMP ortholog

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

6759715..6798941 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001103732.2 → NP_001097202.2 exchange protein directly activated by cAMP, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001097202.2

Status: REVIEWED

UniProtKB/TrEMBL

A1Z6P8

Conserved Domains (6) summary

smart00147
Location:766 → 1002

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

COG0664
Location:28 → 146

Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]

cd00038
Location:352 → 463

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

cd04437
Location:199 → 330

DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...

pfam00618
Location:489 → 594

RasGEF_N; RasGEF N-terminal motif

cl00155
Location:665 → 714

UBQ; Ubiquitin-like proteins
NM_165490.2 → NP_724498.1 exchange protein directly activated by cAMP, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_724498.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7K3Z6

Related

FBpp0111548

Conserved Domains (6) summary

smart00147
Location:621 → 857

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

COG0664
Location:228 → 380

Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]

cd00038
Location:207 → 318

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

cd04437
Location:54 → 185

DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...

pfam00618
Location:344 → 449

RasGEF_N; RasGEF N-terminal motif

cl00155
Location:520 → 569

UBQ; Ubiquitin-like proteins
NM_001273807.1 → NP_001260736.1 exchange protein directly activated by cAMP, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260736.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KF54

Conserved Domains (6) summary

smart00147
Location:695 → 931

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

COG0664
Location:302 → 454

Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]

cd00038
Location:281 → 392

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

cd04437
Location:128 → 259

DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...

pfam00618
Location:418 → 523

RasGEF_N; RasGEF N-terminal motif

cl00155
Location:594 → 643

UBQ; Ubiquitin-like proteins
NM_001273808.1 → NP_001260737.2 exchange protein directly activated by cAMP, isoform H [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KEU1

Conserved Domains (5) summary

smart00147
Location:707 → 943

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

cd00038
Location:293 → 404

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

cd04437
Location:140 → 271

DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...

pfam00618
Location:430 → 535

RasGEF_N; RasGEF N-terminal motif

cl28922
Location:593 → 663

Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold