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    Cyp6a18 Cytochrome P450 6a18 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43304, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cyp6a18provided by FlyBase
    Official Full Name
    Cytochrome P450 6a18provided by FlyBase
    Primary source
    FLYBASE:FBgn0039519
    Locus tag
    Dmel_CG13977
    See related
    AllianceGenome:FB:FBgn0039519
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    6a18; CG13977; cyp6a18; Cyp6A18; CYP6a18; Dmel\CG13977
    Summary
    Predicted to enable several functions, including heme binding activity; iron ion binding activity; and monooxygenase activity. Is expressed in adult head; amnioserosa; embryonic Malpighian tubule; embryonic/larval Malpighian tubule; and yolk nucleus. Human ortholog(s) of this gene implicated in Ghosal hematodiaphyseal syndrome; cerebral infarction; essential hypertension; familial Mediterranean fever; and leukemia (multiple). Orthologous to several human genes including CYP3A7-CYP3A51P (CYP3A7-CYP3A51P readthrough); CYP3A4 (cytochrome P450 family 3 subfamily A member 4); and CYP3A43 (cytochrome P450 family 3 subfamily A member 43). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Cyp6a18 in Genome Data Viewer
    Location:
    98A2-98A2; 3-94 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (27478675..27482904)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (23304397..23308626)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Gustatory receptor 98a Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A multi-layered network model identifies Akt1 as a common modulator of neurodegeneration. Na D, et al. Mol Syst Biol, 2023 Dec 6. PMID 37984409, Free PMC Article
    2. Novel Drosophila model of myotonic dystrophy type 1: phenotypic characterization and genome-wide view of altered gene expression. Picchio L, et al. Hum Mol Genet, 2013 Jul 15. PMID 23525904
    3. Anti-ageing effects of red ginseng on female Drosophila melanogaster. Hou W, et al. J Cell Mol Med, 2020 Mar. PMID 32022406, Free PMC Article
    4. DDT resistance in Drosophila correlates with Cyp6g1 over-expression and confers cross-resistance to the neonicotinoid imidacloprid. Daborn P, et al. Mol Genet Genomics, 2001 Dec. PMID 11810226
    5. Lactobacilli Modulate Epithelial Cytoprotection through the Nrf2 Pathway. Jones RM, et al. Cell Rep, 2015 Aug 25. PMID 26279578, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome P450 6a18
    Names
    CG13977-PA
    CG13977-PB
    Cyp6a18-PA
    Cyp6a18-PB
    cytochrome P450
    NP_001287562.1
    NP_651563.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      27478675..27482904
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300633.1 → NP_001287562.1  cytochrome P450 6a18, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287562.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VB31
      UniProtKB/TrEMBL
      A0A0B4LHU5
      Conserved Domains (1) summary
      pfam00067
      Location:38 → 504
      p450; Cytochrome P450

    2. NM_143306.3 → NP_651563.1  cytochrome P450 6a18, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651563.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VB31
      UniProtKB/TrEMBL
      A0A0B4LHU5
      Related
      FBpp0084553
      Conserved Domains (1) summary
      pfam00067
      Location:38 → 504
      p450; Cytochrome P450
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LHU5 A0A0B4LHU5
    Q9VB31.1 Q9VB31

    Gene LinkOut

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