U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    grass Gram-positive Specific Serine protease [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43273, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    grassprovided by FlyBase
    Official Full Name
    Gram-positive Specific Serine proteaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039494
    Locus tag
    Dmel_CG5896
    See related
    AllianceGenome:FB:FBgn0039494
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    c-SP1; CG5896; cSP1; Dmel\CG5896; Grass; SP1; SP2
    Summary
    Enables calcium ion binding activity. Involved in Toll receptor ligand protein activation cascade; defense response to other organism; and positive regulation of antimicrobial peptide production. Located in extracellular region. Is expressed in embryonic salivary gland duct and embryonic/larval tracheal dorsal trunk. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See grass in Genome Data Viewer
    Location:
    97E5-97E5; 3-92 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (27157948..27159781)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (22983670..22985503)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Malic enzyme b Neighboring gene uncharacterized protein Neighboring gene pickpocket 31 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Structure-function analysis of grass clip serine protease involved in Drosophila Toll pathway activation. Kellenberger C, et al. J Biol Chem, 2011 Apr 8. PMID 21310954, Free PMC Article
    2. The Genome of Drosophila innubila Reveals Lineage-Specific Patterns of Selection in Immune Genes. Hill T, et al. Mol Biol Evol, 2019 Jul 1. PMID 30865231, Free PMC Article
    3. Sensing of 'danger signals' and pathogen-associated molecular patterns defines binary signaling pathways 'upstream' of Toll. El Chamy L, et al. Nat Immunol, 2008 Oct. PMID 18724373, Free PMC Article
    4. The serine protease homolog spheroide is involved in sensing of pathogenic Gram-positive bacteria. Patrnogic J, et al. PLoS One, 2017. PMID 29211760, Free PMC Article
    5. Anthrax toxin component, Protective Antigen, protects insects from bacterial infections. Alameh S, et al. PLoS Pathog, 2020 Aug. PMID 32866212, Free PMC Article

    See all (73) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data found that Grass displays a rather deep active site cleft comparable with that of proteases of coagulation and complement cascades.
      Title: Structure-function analysis of grass clip serine protease involved in Drosophila Toll pathway activation.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables serine hydrolase activity HDA PubMed 
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Toll receptor ligand protein activation cascade IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in Toll receptor ligand protein activation cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response to Gram-positive bacterium IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in defense response to Gram-positive bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response to fungus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in innate immune response IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of antibacterial peptide biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of antifungal peptide production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region HDA PubMed 
    located_in extracellular region IC
    Inferred by Curator
    more info
    		 PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Gram-positive specific serine protease
    Names
    CG5896-PA
    CG5896-PB
    Gram-positive-specific serine protease
    gram-positive specific serine protease
    grass
    grass-PA
    grass-PB
    herrade
    NP_651543.1
    NP_733197.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      27157948..27159781
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_170318.3 → NP_733197.1  Gram-positive specific serine protease, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733197.1

      Status: REVIEWED

      Related
      FBpp0084481
      Conserved Domains (3) summary
      smart00680
      Location:1 → 48
      CLIP; Clip or disulphide knot domain
      smart00020
      Location:76 → 326
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:79 → 329
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    2. NM_143286.3 → NP_651543.1  Gram-positive specific serine protease, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651543.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q86PB3, Q8MR95, Q9VB67, Q9VB68
      Related
      FBpp0084482
      Conserved Domains (2) summary
      smart00680
      Location:32 → 90
      CLIP; Clip or disulphide knot domain
      cd00190
      Location:121 → 371
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VB68.1 Q9VB68

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools