beta4GalT7 beta-4-galactosyltransferase 7 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: beta4GalT7provided by FlyBase
Official Full Name: beta-4-galactosyltransferase 7provided by FlyBase
Primary source: FLYBASE:FBgn0039258
Locus tag: Dmel_CG11780
See related: AllianceGenome:FB:FBgn0039258
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: beta4Gal-T7; beta4GalTI; betaGalT7; CG11780; dbeta4GalT7; Dbeta4GalT7; dbeta4GalTI; dGAGbeta4GalTI; Dmel\CG11780; GalT; GalTI
Summary: Enables xylosylprotein 4-beta-galactosyltransferase activity. Involved in N-glycan processing and proteoglycan biosynthetic process. Located in Golgi apparatus. Is expressed in adult head. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome and Ehlers-Danlos syndrome spondylodysplastic type 1. Orthologous to human B4GALT7 (beta-1,4-galactosyltransferase 7). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 96B16-96B16; 3-86 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (25023256..25024482)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (20848978..20850204)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

identified the Drosophila proteoglycan UDP-galactose:beta-xylose beta1,4-galactosyltransferase I (dbeta4GalTI), and determined its substrate specificity; beta4GalTI is essential for viability
Title: Proteoglycan UDP-galactose:beta-xylose beta 1,4-galactosyltransferase I is essential for viability in Drosophila melanogaster.
identifed a putative Drosophila beta4-galactosyltransferase gene and determined the enzymatic activity of its product; results showed that Drosophila encodes an ortholog of human beta4-galactosyltransferase-VII
Title: Identification and characterization of a Drosophila melanogaster ortholog of human beta1,4-galactosyltransferase VII.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm1624 (e-PCR)
- UniSTS:82724

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables glycosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables xylosylprotein 4-beta-galactosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables xylosylprotein 4-beta-galactosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in N-glycan processing	IDA Inferred from Direct Assay more info	PubMed
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in chondroitin sulfate proteoglycan biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glycosylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in heparan sulfate proteoglycan biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteoglycan biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteoglycan biosynthetic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: beta-4-galactosyltransferase 7

Names: CG11780-PA; beta-1,-4-galactosyltransferase; beta1,4-Galactosyltransferase-7; beta4GalT7-PA; galactosyltransferase I; glycosaminoglycan galactosyltransferase I

NP_651319.2

EC 2.4.-.-

EC 2.4.1.133

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

25023256..25024482

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_143062.3 → NP_651319.2 beta-4-galactosyltransferase 7 [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_651319.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8I6J0, Q8T3P3, Q9VBZ9

Related

FBpp0084130

Conserved Domains (1) summary

cd00899
Location:75 → 299

b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids