U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Polr2M RNA polymerase II subunit M [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42309, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Polr2Mprovided by FlyBase
    Official Full Name
    RNA polymerase II subunit Mprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038692
    Locus tag
    Dmel_CG3773
    See related
    AllianceGenome:FB:FBgn0038692
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:fe2D10; anon-EST:fe2D12; CG3773; Dmel\CG3773; Gdn1; Gdown1
    Summary
    Predicted to enable transcription elongation factor activity. Predicted to be involved in transcription elongation by RNA polymerase II. Part of RNA polymerase II, core complex. Orthologous to human POLR2M (RNA polymerase II subunit M). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Polr2M in Genome Data Viewer
    Location:
    91F12-91F12; 3-66 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (19229463..19230832)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (15055185..15056554)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncoordinated 79 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Architecture of Pol II(G) and molecular mechanism of transcription regulation by Gdown1. Jishage M, et al. Nat Struct Mol Biol, 2018 Sep. PMID 30190596, Free PMC Article
    2. RNA polymerase II pausing during development. Gaertner B, et al. Development, 2014 Mar. PMID 24595285, Free PMC Article
    3. Dominant suppressor genes of p53-induced apoptosis in Drosophila melanogaster. Szlanka T, et al. G3 (Bethesda), 2024 Sep 4. PMID 38985658, Free PMC Article
    4. In silico identification of Drosophila melanogaster genes encoding RNA polymerase subunits. Marygold SJ, et al. MicroPubl Biol, 2020 Oct 20. PMID 33274328, Free PMC Article
    5. A screen for fast evolving genes from Drosophila. Schmid KJ, et al. Proc Natl Acad Sci U S A, 1997 Sep 2. PMID 9275195, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables transcription elongation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in transcription elongation by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of RNA polymerase II, core complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RNA polymerase II, core complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    RNA polymerase II subunit M
    Names
    CG3773-PA
    Gdown1
    Polr2M-PA
    anon-fast-evolving-2D10
    anon-fast-evolving-2D12

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      19229463..19230832
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142537.2 → NP_650794.1  RNA polymerase II subunit M [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650794.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C0PTU7, Q9VDY6
      Related
      FBpp0083151
      Conserved Domains (1) summary
      pfam15328
      Location:39 → 233
      GCOM2; Putative GRINL1B complex locus protein 2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MQV7 Q8MQV7
    Q9VDY6 Q9VDY6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools