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    Adgf-D Adenosine deaminase-related growth factor D [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41679, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Adgf-Dprovided by FlyBase
    Official Full Name
    Adenosine deaminase-related growth factor Dprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038172
    Locus tag
    Dmel_CG9621
    See related
    AllianceGenome:FB:FBgn0038172
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    ADGF-D; adgfd; AdgfD; ADGFD; CG9621; Dmel\CG9621
    Summary
    Enables adenosine deaminase activity. Involved in adenosine catabolic process and positive regulation of cell population proliferation. Located in extracellular space. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in Sneddon syndrome. Orthologous to human ADA2 (adenosine deaminase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Adgf-D in Genome Data Viewer
    Location:
    87F11-87F11; 3-54 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (13703084..13705402, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (9528806..9531124, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene oocyte maintenance defects Neighboring gene falafel Neighboring gene uncharacterized protein Neighboring gene flyers-cup Neighboring gene neither inactivation nor afterpotential B Neighboring gene Adenosine deaminase-related growth factor C Neighboring gene Arginine phosphatase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Oxygenation and adenosine deaminase support growth and proliferation of ex vivo cultured Drosophila wing imaginal discs. Strassburger K, et al. Development, 2017 Jul 1. PMID 28526754
    2. Genetic analysis of the ADGF multigene family by homologous recombination and gene conversion in Drosophila. Dolezal T, et al. Genetics, 2003 Oct. PMID 14573477, Free PMC Article
    3. Adenosine deaminase-related growth factors stimulate cell proliferation in Drosophila by depleting extracellular adenosine. Zurovec M, et al. Proc Natl Acad Sci U S A, 2002 Apr 2. PMID 11904370, Free PMC Article
    4. Increased extracellular adenosine in Drosophila that are deficient in adenosine deaminase activates a release of energy stores leading to wasting and death. Zuberova M, et al. Dis Model Mech, 2010 Nov-Dec. PMID 20940317
    5. The invertebrate growth factor/CECR1 subfamily of adenosine deaminase proteins. Charlab R, et al. Gene, 2001 Apr 4. PMID 11311551

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables adenosine deaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables adenosine deaminase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables adenosine deaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in adenosine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in adenosine catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in adenosine catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in inosine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    adenosine deaminase-related growth factor D
    Names
    Adgf-D-PA
    CG9621-PA
    adenosine deaminase-related growth factor A2
    NP_524345.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      13703084..13705402 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079621.3 → NP_524345.2  adenosine deaminase-related growth factor D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524345.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8WS96, Q9VFS1
      Related
      FBpp0082310
      Conserved Domains (3) summary
      cd01321
      Location:80 → 490
      ADGF; Adenosine deaminase-related growth factors (ADGF), a novel family of secreted growth-factors with sequence similarty to adenosine deaminase.
      TIGR01431
      Location:27 → 498
      adm_rel; adenosine deaminase-related growth factor
      pfam08451
      Location:4 → 100
      A_deaminase_N; Adenosine/AMP deaminase N-terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VFS1 Q9VFS1

    Gene LinkOut

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