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    ArgRS-m Arginyl-tRNA synthetase, mitochondrial [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40929, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ArgRS-mprovided by FlyBase
    Official Full Name
    Arginyl-tRNA synthetase, mitochondrialprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037526
    Locus tag
    Dmel_CG10092
    See related
    AllianceGenome:FB:FBgn0037526
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    atl; CG10092; Dmel\CG10092
    Summary
    Predicted to enable arginine-tRNA ligase activity. Predicted to be involved in arginyl-tRNA aminoacylation and mitochondrial translation. Located in mitochondrion. Is expressed in organism. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 6. Orthologous to human RARS2 (arginyl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ArgRS-m in Genome Data Viewer
    Location:
    84E4-84E4; 3-48 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (7887045..7890150)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (3712767..3715872)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR46127 Neighboring gene mitochondrial ribosomal protein S9 Neighboring gene water witch Neighboring gene ER membrane protein complex subunit 1 Neighboring gene TBP-associated factor 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An efficient genetic screen in Drosophila to identify nuclear-encoded genes with mitochondrial function. Liao TS, et al. Genetics, 2006 Sep. PMID 16849596, Free PMC Article
    2. The aminoacyl-tRNA synthetases of Drosophila melanogaster. Lu J, et al. Fly (Austin), 2015. PMID 26761199, Free PMC Article
    3. Drosophila follicle stem cells are regulated by proliferation and niche adhesion as well as mitochondria and ROS. Wang ZA, et al. Nat Commun, 2012 Apr 3. PMID 22473013, Free PMC Article
    4. Towards comprehensive annotation of Drosophila melanogaster enzymes in FlyBase. Garapati PV, et al. Database (Oxford), 2019 Jan 1. PMID 30689844, Free PMC Article
    5. Adaptation to Chronic Nutritional Stress Leads to Reduced Dependence on Microbiota in Drosophila melanogaster. Erkosar B, et al. mBio, 2017 Oct 24. PMID 29066546, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables arginine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables arginine-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables arginine-tRNA ligase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in arginyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in arginyl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in arginyl-tRNA aminoacylation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in mitochondrial translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Arginyl-tRNA synthetase, mitochondrial
    Names
    ArgRS-m-PA
    ArgRS-m-PB
    CG10092-PA
    CG10092-PB
    arginyl tRNA ligase
    NP_001262351.1
    NP_649745.3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      7887045..7890150
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275422.1 → NP_001262351.1  Arginyl-tRNA synthetase, mitochondrial, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262351.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SXK2, Q9VHZ0
      Conserved Domains (3) summary
      COG0018
      Location:67 → 594
      ArgS; Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]
      cl00015
      Location:137 → 397
      nt_trans; nucleotidyl transferase superfamily
      cl12020
      Location:436 → 594
      Anticodon_Ia_like; Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains

    2. NM_141488.3 → NP_649745.3  Arginyl-tRNA synthetase, mitochondrial, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649745.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SXK2, Q9VHZ0
      Related
      FBpp0081249
      Conserved Domains (3) summary
      COG0018
      Location:67 → 594
      ArgS; Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]
      cl00015
      Location:137 → 397
      nt_trans; nucleotidyl transferase superfamily
      cl12020
      Location:436 → 594
      Anticodon_Ia_like; Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SXK2 Q8SXK2

    Gene LinkOut

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