SecS Sec synthetase [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: SecSprovided by FlyBase
Official Full Name: Sec synthetaseprovided by FlyBase
Primary source: FLYBASE:FBgn0037347
Locus tag: Dmel_CG1427
See related: AllianceGenome:FB:FBgn0037347
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG1427; Dmel\CG1427
Summary: Predicted to enable tRNA binding activity. Predicted to be involved in selenocysteine incorporation. Is expressed in embryonic brain; larval ventral nerve cord; organism; and ventral nerve cord primordium. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 2D. Orthologous to human SEPSECS (Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 83B4-83B4; 3-47.5 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (5601433..5603185)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (1427155..1428907)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm0563 (e-PCR)
- UniSTS:78680

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables O-phosphoseryl-tRNA(Sec) selenium transferase activity	IEA Inferred from Electronic Annotation more info
enables tRNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in conversion of seryl-tRNAsec to selenocys-tRNAsec	IEA Inferred from Electronic Annotation more info
involved_in selenocysteine incorporation	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Sec synthetase

Names: CG1427-PC; CG1427-PD; CG1427-PE; SecS-PC; SecS-PD; SecS-PE

NP_001262290.1

EC 2.-.-.-

EC 2.9.1.-

EC 2.9.1.2

NP_649556.3

EC 2.-.-.-

EC 2.9.1.-

EC 2.9.1.2

NP_996155.2

EC 2.-.-.-

EC 2.9.1.-

EC 2.9.1.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

5601433..5603185

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_141299.3 → NP_649556.3 Sec synthetase, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_649556.3

Status: REVIEWED

UniProtKB/TrEMBL

B6IDR0, Q4V5V4, Q9VNE3

Conserved Domains (1) summary

cl18945
Location:12 → 457

AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...
NM_001275361.1 → NP_001262290.1 Sec synthetase, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262290.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KF37

Conserved Domains (1) summary

cl18945
Location:12 → 83

AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...
NM_206433.2 → NP_996155.2 Sec synthetase, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_996155.2

Status: REVIEWED

UniProtKB/TrEMBL

A0A0C4DHG1, Q4V5V4

Conserved Domains (1) summary

cl18945
Location:12 → 455

AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...