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    CG14669 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40652, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG14669provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037326
    Locus tag
    Dmel_CG14669
    See related
    AllianceGenome:FB:FBgn0037326
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG14669; Q9VNB7
    Summary
    Predicted to enable GTP binding activity and GTPase activity. Is expressed in adult head. Orthologous to several human genes including RASL10A (RAS like family 10 member A). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG14669 in Genome Data Viewer
    Location:
    83A2-83A4; 3-47.5 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (5414527..5458394)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (1240249..1284116)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Odorant receptor co-receptor Neighboring gene uncharacterized protein Neighboring gene pancreatic eIF-2alpha kinase Neighboring gene Ribosomal protein L35A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Belly roll, a GPI-anchored Ly6 protein, regulates Drosophila melanogaster escape behaviors by modulating the excitability of nociceptive peptidergic interneurons. Li K, et al. Elife, 2023 Jun 13. PMID 37309249, Free PMC Article
    2. Formation and function of intracardiac valve cells in the Drosophila heart. Lammers K, et al. J Exp Biol, 2017 May 15. PMID 28254880
    3. Orb2 enables rare-codon-enriched mRNA expression during Drosophila neuron differentiation. Stewart RK, et al. Nat Commun, 2024 Jun 20. PMID 38902233, Free PMC Article
    4. Genome-wide identification and characterization of tissue-specific RNA editing events in D. melanogaster and their potential role in regulating alternative splicing. Mazloomian A, et al. RNA Biol, 2015. PMID 26512413, Free PMC Article
    5. CRISPR-based modular assembly of a UAS-cDNA/ORF plasmid library for more than 5500 Drosophila genes conserved in humans. Wei P, et al. Genome Res, 2020 Jan. PMID 31722958, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    mobile_element

    • Loc: 5446016-5452418 mobile_element_type = transposon:Burdock{}1221

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG14669-PA
    CG14669-PB
    CG14669-PC
    CG14669-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      5414527..5458394
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275352.2 → NP_001262281.1  uncharacterized protein Dmel_CG14669, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262281.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VNB7
      Conserved Domains (2) summary
      smart00010
      Location:96 → 265
      small_GTPase; Small GTPase of the Ras superfamily; ill-defined subfamily
      cl21455
      Location:95 → 267
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. NM_141280.3 → NP_649537.5  uncharacterized protein Dmel_CG14669, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649537.5

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VNB7
      Conserved Domains (2) summary
      smart00010
      Location:96 → 265
      small_GTPase; Small GTPase of the Ras superfamily; ill-defined subfamily
      cl21455
      Location:95 → 267
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    3. NM_001316556.1 → NP_001303485.1  uncharacterized protein Dmel_CG14669, isoform D [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      C4IXW2

    4. NM_001300244.1 → NP_001287173.1  uncharacterized protein Dmel_CG14669, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287173.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LHR5
      Conserved Domains (2) summary
      COG1100
      Location:95 → 176
      Gem1; GTPase SAR1 family domain [General function prediction only]
      cl21455
      Location:95 → 156
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LHR5 A0A0B4LHR5
    C4IXW2 C4IXW2
    Q9VNB7 Q9VNB7

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